Seminars

The Mechanisms of Environmental Chemical Toxicity Research Core has used the SWEHSC seminar program as an opportunity to invite investigators whose research or technology will be of benefit to Core members.

Seminar Speakers Associated with the Pulmonary Toxicology and Lung Disease Research Core

Date	Speaker	Institution	Topic
01/15/99	Robert Finkelman Host: Aposhian	US Geological Survey, Washington DC	Health Impact of Domestic Coal Combustion in China
03/11/99	John Pritchard Host: Wright	Pharmacology and Chemistry, NIEHS, RTP	Excretory Transport: The ‘Other’ Path to Xenobiotic Detoxification
03/17/99	Phillip Stork Host: Vaillancourt	The Vollum Institute, Oregon Health Sciences University	Cell-type Specific Regulation of the MAP Kinase Cascade
03/31/99	Michael Lieberman Host: Liebler	Baylor University College of Medicine	CGST Transgenic Mouse Models – impact on arsenic toxicity - Keynote speaker “New Technologies Symposium
04/06/99	Laurie G. Hudson Host: Vaillancourt	Dept Pharmacol & Toxicol, University of New Mexico	Receptor Tyrosine Kinase Regulation of Keratinocyte Migration and Invasion
05/03/99	Dean Jones Host: Liebler	Department of Biochemistry, Emory University	Mitochondrial Redox Signaling of Apoptosis
06/09/99	Mike Winrow Host: Gandolfi	Proctor & Gamble	Changing paradigm of research in pharmaceutical industry
10/27/99	Grushenka Wolfgang Host: Gandolfi	Chiron, Preclinical Development	Safety Assessment of Biologies and Biotechnology Derived Products
11/05/99	Kenneth Ramos Host: McQueen	Dept Physiol/Pharmacology Texas A & M University	Regulation of Mammalian Gene Expression via the Antioxidant Response
03/15/01	David Miller Host: Wright	NIEHS	Imaging Drug Transporter Function at the Blood-Brain and Blood-CNS Barriers
04/19/01	Philip Mirkes Host: Runyan	Dept Pediatrics University of Washington	Biochemistry of teratogen-induced apoptosis in early mouse embryos
04/27/01	Peter Guengerich Host: Liebler	Vanderbilt University	Reactive Intermediates in Toxicology: Past, Present, and Future
05/03/01	Pope Mosely Host: Liebler	University of New Mexico, Center for Env Health	Heat Shock Proteins as Biomarkers in Environmental Stress
03/29/02	Douglas Gray Host: Gandolfi	University of Ottawa	The surprising effects of mutant ubiquitin in transgenic mice
05/16/02	Joshua Hamilton Host: Vaillancourt	Dartmouth Medical School	Arsenic as an endocrine Disruptor
03/24/03	Toby Rossman Host: Gandolfi	New York University School of Medicine	Molecular mechanisms of arsenic resistance
04/18/03	John Pritchard Host: Wright	NIEHS	The drug transporter OAT3: From gene to knockout to mechanism
05/16/03	Jodi Flaws Host: Hoyer	University of Maryland	Effects of methoxyclor and kepone on mammalian ovary
11/18/03	Patricia Ostrosky Host: Aposhian	Universidad Nacional Autonoma de Mexico	Genotoxity of arsenic

Pilot Projects

Investigators from the Mechanisms of Environmental Chemical Toxicity Research Core have competed successfully for Pilot Projects awarded from the SWEHSC. These Pilot Project applications have been used to “open” new doors of research (e.g. arsenic effect on ubiquitin pathway), attract new investigators to examine the toxic effects of arsenic (e.g. polymorphism of arsenic biotransformation enzymes, regulation transport to testes), and stimulate collaborations between Mechanisms of Environmental Chemical Toxicity Research Core Investigators and other investigators (e.g. Gandolfi-Liebler).

The impact of the Pilot Project Grants has been substantial, and has led to new NIH grants for Drs. Wright/Dantzler (environmental pollutant transport studies), Dr. Vaillancourt (effect of arsenic on signaling processes – Proteomics), and Dr. Gandolfi (development of tissue chips as in vitro system) as well as new NSF funding for Dr. Runyan (develop CMOS chips), and supplements to the Superfund grant (Gandolfi, Vaillancourt). Dr. Cherrington’s Pilot Project grant on the importance of transporters on the accumulation and excretion of toxicants in the testes is already being developed into grant proposals for the NIH.

Pilot Project Involvement of Core Members

Investigator	Collaborator	Year	Project Title (Resulting funding and publications)
Dantzler	Wright	1998	Multiple pathways for xenobiotic organic anion excretion in renal tubules (RO1 DK58251; 3 publications)
Gandolfi	Liebler	1999	Alterations in the ubiquitin pathway as an indicator of low-level arsenic toxicity (2 publications, 10 abstracts)
Vaillancourt	Liebler	1999	Identification of proteins that interact with MEKK3 (RO1 AG19710; 3 publications)
Wright	Dantzler	1999	Transport of arsenic containing compounds by cloned renal transport proteins (PO1 ES04940; 4 publications)
Vaillancourt		2000	Analysis of phosphoproteins from cadmium-transformed epithelial cells (RO1 ES12007; 1 publication)
Gandolfi		2000	Precision-cut slices from transgenic mice as an in vitro toxicology system. (R41 ES10668; R33 CA97449; 1 publication, 5 abstracts)
Runyan	Arnold	2001	Development of CMOS biochip for proteomics and toxicity testing. (NSF, NSF/SRC) (Patents pending)
Selmin	Romagnolo	2001/ 2002	Dioxin and estrogen interactions on regulation of the mPR
Klimecki	Gandolfi	2002	Genetic variation in arsenic metabolism (Added to Superfund Grant Renewal; 1 publication
Cherrington		2003	Role of transporters in the blood-testis barrier