Mechanisms
of Environmental Chemical Toxicity Research Core
The Mechanisms of Environmental Chemical Toxicity Research Core
encompasses SWEHSC investigators who are studying fundamental mechanisms
of cellular toxicity.
The
primary goal of the Mechanisms of Environmental Chemical Toxicity
Research Core is to determine the critical mechanisms by which
environmental pollutants produce their toxic effects.
Arsenic is
the principal toxicant of interest for several of the Core investigators,
but reproductive and developmental toxicants (vinyl cyclohexene,
amino biphenyls, PAHs, and trichloroethylene), and renal toxicants
(cysteine conjugates), are also under investigation.
The
Mechanisms of Environmental Chemical Toxicity Research Core consists
of twelve investigators, representing three Colleges (Pharmacy,
Medicine, and Science) and six Departments/Divisions (Pharmacology & Toxicology,
Physiology, Respiratory Sciences, Nutritional Sciences, Cell Biology & Anatomy,
and Molecular & Cellular Biology).
Recent
publications by members of the core. For a complete list of publications
click here.
2004
*Aposhian,
H. V., Zakharyan, R. A., Healy, S. M., Wildfang, E., Petrick,
J. S., Sampayo-Reyes, A., Board, P. G., Carter,
D. E.,
Guhu Mazumder, D. N., and Aposhian, M. M. (2004). Enzymology
and Toxicity of Inorganic Arsenic. In: Arsenic Exposure
and Health Effects V. (W. R. Chappel, C. O. Abernathy,
and R. L. Calderon, Eds.), Elsevier Scientific Ltd.
*Derbyshire, Z. E., Halfter, U. M., Heimark, R. L.,
and Vaillancourt, R. R. (2004) Angiotensin II stimulated
transcription of cyclooxygenase II is regulated by a novel
kinase cascade involving Pyk2, MEKK4 and annexin II. Mol.
Cell. Biol., Submitted.
*Kaewmokul, S., Chatsudthipong, V., Evans, K. K.,
Dantzler, W. H., and Wright, S.
H. (2004). Functional Mappig
of rbOCT1 and rbOCT2 Activity in the S2 Segment of Rabbit
Proximal Tubule. Am. J. Physiol. (Renal Physiol.), In Press.
Kirkpatrick, D. D., Weldon, S. F., Tsaprailis, G.,
Liebler, D. C., and Gandolfi, A. J. (2004). Qualitative and
quantitative analysis of charges in the ubiquitin pathway
in human cells using LC-MS/MS. Mol. Cell. Proteomics, Submitted.
*Lungkaphin, A., Chatsudthipong, V., Evans, K. K.,
Groves, C. E., Wright, S. H., and Dantzler, W. H. (2004).
Interaction of the Metal Chelator, DMPS, with OAT1 and OAT3
in Intact Isolated Rabbit Renal Proximal Tubules. Am. J.
Physiol. (Renal Physiol.), In Press.
Nyman, D., Marshall, J., Nagle, R. B., and Gandolfi,
A. J. (2004). Selenium and selenomethione levels in prostate
cancer patients. Cancer Detect. And Prevent., In Press.
*Peraza, M. A., Carter,
D. E., and Gandolfi,
A. J. (2004). Toxicity and metabolism of subcytotoxic inorganic
arsenic in human renal proximal tubule epithelial cells (HK-2).
Cell Biol Toxicol 19, 253-264.
*Scott, N., Gufang Z., Aposhian,
H. V., and Carter,
D. E. (2004). Mass spectrometry of toxicologically significant
arsenic-thiol species. Chem. Res. Toxicol., Submitted.
Bredfeldt, T. G., Kirkpatrick, D. S., Kopplin, M.,
and Gandolfi, A. J. (2004) Effect of low-level arsenite exposure
on UROsta cells. Production of ubiquinated proteins and stimulation
by BSO. Toxicol. Appl. Pharmacol., In Press.
Rose, R. L., Tang, J., Coi, J., Cao, Y., Usmani, A.,
and Cherrington, N. J. (2004) Pesticide metabolism in humans,
including polymorphisms. Scan. J. Work Environ. Health, In
Press.
Southwest
Environmental Health Sciences Center
University of Arizona College of Pharmacy, Room 244
PO Box 210207, Tucson, AZ, USA 85721-0207 swehsc-info@pharmacy.arizona.edu
520-626-5594
520-626-6944(FAX)
