Publications of Research Core 1 Investigators, 1999-2004.

Printable List of Publications in .pdf format

1. *Abernathy, C.O., Liu, Y.P., Longfellow, D., Aposhian, H.V., Beck, B., Fowler, B., Goyer, R., Menzer, R., Rossman, T., Thompson, C., and Waalkes, M. (1999). Arsenic: health effects, mechanisms of actions, and research issues. Environ. Health Perspect. 107, 593-597.

2. Ayala-Fierro, F., Barber, D. S., Rael, L. T., and Carter, D. E. (1999). In vitro tissue specificity for arsine and arsenite toxicity in the rat. Toxicol. Sci. 52, 122-129.

3. *Ben Jonathan, N., Cooper, R. L., Foster, P., Hughes, C. L., Hoyer, P. B., Klotz, D., Kohn, M., Lamb, D. J., and Stancel, G. M. (1999). An approach to the development of quantitative models to assess the effects of exposure to environmentally relevant levels of endocrine disruptors on homeostasis in adults. Environ. Health Perspect. 107 Suppl. 4, 605-611.

4. Borman, S. M., VanDePol, B. J., Kao, S., Thompson, K. E., Sipes, I. G., and Hoyer, P. B. (1999). A single dose of the ovotoxicant 4-vinylcyclohexene diepoxide is protective in rat primary ovarian follicles. Toxicol. Appl. Pharmacol. 158, 244-252.

5. Brokl, O. H. and Dantzler, W. H. (1999). Amino acid fluxes in rat thin limb segments of Henle's loop during in vitro microperfusion. Am. J. Physiol 277, F204-F210.

6. Chatsudthipong, V., Jutabha, P., Evans, K. K., and Dantzler, W. H. (1999). Effects of inhibitors and substitutes for chloride in lumen on p-aminohippurate transport by isolated perfused rabbit renal proximal tubules. J. Pharmacol. Exp. Ther. 288, 993-1001.

7. Dang, L. N. and McQueen, C. A. (1999). Mutagenicity of 4-aminobiphenyl and 4-acetylaminobiphenyl in Salmonella typhimurium strains expressing different levels of N-acetyltransferase. Toxicol. Appl. Pharmacol. 159, 77-82.

8. Diawara, M. M., Chavez, K. J., Hoyer, P. B., Williams, D. E., Dorsch, J., Kulkosky, P., and Franklin, M. R. (1999). A novel group of ovarian toxicants: the psoralens. J. Biochem. Mol. Toxicol. 13, 195-203.

9. Divine, K. K., Ayala-Fierro, F., Barber, D. S., and Carter, D. E. (1999). Glutathione, albumin, cysteine, and cys-gly effects on toxicity and accumulation of mercuric chloride in LLC-PK1 cells. J. Toxicol. Environ. Health A 57, 489-505.

10. Firriolo, J. M., Ayala-Fierro, F., Sipes, I. G., and Carter, D. E. (1999). Absorption and disposition of cobalt naphthenate in rats after a single oral dose. J. Toxicol. Environ. Health A 58, 383-395.

11. *Gekle, M., Mildenberger, S., Sauvant, C., Bednarczyk, D., Wright, S. H., and Dantzler, W. H. (1999). Inhibition of initial transport rate of basolateral organic anion carrier in renal PT by BK and phenylephrine. Am. J. Physiol 277, F251-F256.

12. *Goering, P. L., Aposhian, H. V., Mass, M. J., Cebrian, M., Beck, B. D., and Waalkes, M. P. (1999). The enigma of arsenic carcinogenesis: role of metabolism. Toxicol. Sci. 49, 5-14.

13. *Healy, S. M., Wildfang, E., Zakharyan, R. A., and Aposhian, H. V. (1999). Diversity of inorganic arsenite biotransformation. Biol. Trace Elem. Res. 68, 249-266.

14. *Hoyer, P. B. (1999). Ovotoxic environmental chemicals: Indirect endocrine disruptors. In: Endocrine Disruptors: Effects on Male and Female Reproductive Systems (R. Naz, Ed.), pp. 57-88. CRC Press, Boca Raton, FL.

15. *Hoyer, P. B., Marion, S. L., Stine, I., Rueda, B. R., Hamernik, D. L., Regan, J. W., and Wise, M. E. (1999). Ovine prostaglandin F2? receptor: steroid influence on steady-state levels of luteal mRNA. Endocrine. 10, 105-111.

16. Ingersoll, R. T., Montgomery, E. B., Jr., and Aposhian, H. V. (1999). Central nervous system toxicity of manganese. II: Cocaine or reserpine inhibit manganese concentration in the rat brain. Neurotoxicology 20, 467-476.

17. Jeffy, B. D., Schultz, E. U., Selmin, O., Gudas, J. M., Bowden, G. T., and Romagnolo, D. (1999). Inhibition of BRCA-1 expression by benzo[a]pyrene and its diol epoxide. Mol. Carcinog. 26, 100-118.

18. Kao, S. W., Sipes, I. G., and Hoyer, P. B. (1999). Early effects of ovotoxicity induced by 4-vinylcyclohexene diepoxide in rats and mice. Reprod. Toxicol. 13, 67-75.

19. *Keith, R. L., Gandolfi, A. J., McIntyre L. C. Jr, Ashbaugh, M. D., and Fernando, Q. (1999). Analysis of heavy metal deposition in renal tissue by sectional mapping using PIXE. Nuclear Instruments and Methods in Physics Research B 149, 167-176.

20. Lind, R. C. and Gandolfi, A. J. (1999). Hepatoprotection by dimethyl sulfoxide. I. Protection when given twenty-four hours after chloroform or bromobenzene. Toxicol. Pathol. 27, 342-347.

21. Lind, R. C. and Gandolfi, A. J. (1999). Hepatoprotection by dimethyl sulfoxide. II. Characterization of optimal dose and the latest time of administration for effective protection against chloroform and bromobenzene induced injury. Exp. Toxicol. Pathol. 51, 537-543.

22. Mitchell, M. K., Futscher, B. W., and McQueen, C. A. (1999). Developmental expression of N-acetyltransferases in C57BI/6 mice. Drug Metab. Dispos. 27, 261-264.

23. Parrish, A. R., Catania, J. M., Orozco, J., and Gandolfi, A. J. (1999). Chemically induced oxidative stress disrupts the E-cadherin/catenin cell adhesion complex. Toxicol. Sci. 51, 80-86.

24. Parrish, A. R., Zheng, X. H., Turney, K. D., Younis, H. S., and Gandolfi, A. J. (1999). Enhanced transcription factor DNA binding and gene expression induced by arsenite or arsenate in renal slices. Toxicol. Sci. 50, 98-105.

25. *Runyan, R. B., Wendler, C. C., Romano, L. A., Boyer, A. S., Dagle, J. M., and Weeks, D. L. (1999). Utilization of antisense oligodeoxynucleotides with embryonic tissues in culture. Methods 18, 316-321.

26. Shuprisha, A., Lynch, R. M., Wright, S. H., and Dantzler, W. H. (1999). Real-time assessment of alpha-ketoglutarate effect on organic anion secretion in perfused rabbit proximal tubules. Am. J. Physiol. 277, F513-F523.

27. Stevens, G. J., Payton, M., Sim, E., and McQueen, C. A. (1999). N-acetylation of the heterocyclic amine batracylin by human liver. Drug Metab. Dispos. 27, 966-971.

28. Wei, H., Qiu, L., Divine, K. K., Ashbaugh, M. D., McIntyre, L. C., Jr., Fernando, Q., and Gandolfi, A. J. (1999). Toxicity and transport of three synthesized mercury-thiol-complexes in isolated rabbit renal proximal tubule suspensions. Drug Chem. Toxicol. 22, 323-341.

29. Wright, S. H. and Wunz, T. M. (1999). Influence of substrate structure on substrate binding to the renal organic cation/H+ exchanger. Pflugers Arch. 437, 603-610.

30. *Zakharyan, R. A. and Aposhian, H. V. (1999). Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase. Chem. Res. Toxicol. 12, 1278-1283.

31. Zakharyan, R. A. and Aposhian, H. V. (1999). Arsenite methylation by methylvitamin B12 and glutathione does not require an enzyme. Toxicol. Appl. Pharmacol. 154, 287-291.

32. Aposhian, H. V., Gurzau, E. S., Le, X. C., Gurzau, A., Healy, S. M., Lu, X., Ma, M., Yip, L., Zakharyan, R. A., Maiorino, R. M., Dart, R. C., Tircus, M. G., Gonzalez-Ramirez, D., Morgan, D. L., Avram, D., and Aposhian, M. M. (2000). Occurrence of monomethylarsonous acid in urine of humans exposed to inorganic arsenic. Chem. Res. Toxicol. 13, 693-697.

33. Aposhian, H. V., Zheng, B., Aposhian, M. M., Le, X. C., Cebrian, M. E., Cullen, W., Zakharyan, R. A., Ma, M., Dart, R. C., Cheng, Z., Andrewes, P., Yip, L., O'Malley, G. F., Maiorino, R. M., Van Voorhies, W., Healy, S. M., and Titcomb, A. (2000). DMPS-arsenic challenge test. II. Modulation of arsenic species, including monomethylarsonous acid (MMA(III)), excreted in human urine. Toxicol. Appl. Pharmacol. 165, 74-83.

34. Ayala-Fierro, F., Baldwin, A. L., Wilson, L. M., Valeski, J. E., and Carter, D. E. (2000). Structural alterations in the rat kidney after acute arsine exposure. Lab. Invest. 80, 87-97.

35. *Ayala-Fierro, F. and Carter, D. E. (2000). LLC-PK1 cells as a model for renal toxicity caused by arsine exposure. J. Toxicol. Environ. Health 60, 67-79.

36. *Bednarczyk, D., Mash, E. A., Aavula, B. R., and Wright, S. H. (2000). NBD-TMA: a novel fluorescent substrate of the peritubular organic cation transporter of renal proximal tubules. Pflugers Arch. 440, 184-192.

37. Borman, S. M., Christian, P. J., Sipes, I. G., and Hoyer, P. B. (2000). Ovotoxicity in female Fischer rats and B6 mice induced by low-dose exposure to three polycyclic aromatic hydrocarbons; Comparison through calculation of an Ovotoxic Index. Toxicol. Appl. Pharmacol. 167, 191-198.

38. Boyer, A. S., Finch, W. T., and Runyan, R. B. (2000). Trichloroethylene inhibits development of embryonic heart valve precursors in vitro. Toxicol. Sci. 53, 109-117.

39. Burkey, J. L., Sauer, J., McQueen, C. A., and Sipes, I. G. (2000). Cytotoxicity and genotoxicity of methyleugenol and related congeners - a mechanism of activation for methyleugenol. Mutat. Res. 453, 25-33.

40. Dantzler, W. H., Kim, Y. K., Abbott, D. E., Serrano, O. K., and Brokl, O. H. (2000). Intracellular pH in isolated rat renal papillary thin limbs of Henle's loop. Pflugers Arch. 440, 140-148.

41. *Devine, P. J., Payne, C. M., McCuskey, M. K., and Hoyer, P. B. (2000). Ultrastructural evaluation of oocytes during atresia in rat ovarian follicles. Biology of Reproduction 63, 1245-1252.

42. *Gailer, J., George, G. N., Pickering, I. J., Madden, S., Prince, R. C., Yu, E. Y., Denton, M. B., Younis, H. S., and Aposhian, H. V. (2000). Structural basis of the antagonism between inorganic mercury and selenium in mammals. Chem. Res. Toxicol. 13, 1135-1142.

43. Ito, Y., Lind, R. C., Begay, C. K., Gandolfi, A. J., McCuskey, M. K., and McCuskey, R. S. (2000). Late administration of dimethyl sulfoxide minimizes the hepatic microvascular inflammatory response to chloroform in rats. Hepatology Research 18, 203-217.

44. *Le, X. C., Ma, M., Cullen, W. R., Aposhian, H. V., Lu, X., and Zheng, B. (2000). Determination of monomethylarsonous acid, a key arsenic methylation intermediate, in human urine. Environ. Health Perspect. 108, 1015-1018.

45. *Le, X. C., Lu, X., Ma, M., Cullen, W. R., Aposhian, H. V., and Zheng, B. (2000). Speciation of key arsenic metabolic intermediates in human urine. Anal. Chem. 72, 5172-5177.

46. Lind, R. C., Begay, C. K., and Gandolfi, A. J. (2000). Hepatoprotection by dimethyl sulfoxide. III. Role of inhibition of the bioactivation and covalent bonding of chloroform. Toxicol. Appl. Pharmacol. 166, 145-150.

47. McQueen, C. A. and Norman, J. K. (2000). Toxicology: questions and answers. Toxicol. Sci. 54, 65.

48. McQueen, C. A. and Yost, G. S. (2000). Toxicology for kids: the classroom experience. Toxicol. Sci. 54, 65.

49. *Mitchell, R. D., Ayala-Fierro, F., and Carter, D. E. (2000). Systemic Indicators of Inorganic Arsenic Toxicity in Four Animal Species. J. Toxicol. Environ. Health 59, 119-134.

50. Norman, J. K., Steinberg, B. D., Gotsch, A. R., Schlegel, B., Weidner, B. L., and McQueen, C. A. (2000). The ToxRAP network: a successful model for bringing toxicology to schools. Toxicol. Sci. 54, 252.

51. Pannabecker, T. L., Volker, K., Silbernagl, S., and Dantzler, W. H. (2000). Cycloleucine fluxes during rat vasa recta and loop microinfusions in vivo and loop microperfusions in vitro. Pflugers Arch. 439, 517-523.

52. Pannabecker, T. L., Dahlmann, A., Brokl, O. H., and Dantzler, W. H. (2000). Mixed descending- and ascending-type hin limbs of Henle's loop in mammalian renal inner medulla. Am. J. Physiol. Renal Physiol. 278, F202-F208.

53. Porter, A. C., Fanger, G. R., and Vaillancourt, R. R. (2000). Signal Transduction pathways regulated by arsenate and arsenite. Oncogene 18, 7794-7802.

54. *Radabaugh, T. R. and Aposhian, H. V. (2000). Enzymatic reduction of arsenic compounds in mammalian systems: reduction of arsenate to arsenite by human liver arsenate reductase. Chem. Res. Toxicol. 13, 26-30.

55. *Rael, L. T., Ayala-Fierro, F., and Carter, D. E. (2000). The effects of sulfur, thiol, and thiol inhibitor compounds on arsine- induced toxicity in the human erythrocyte membrane. Toxicol. Sci. 55, 468-477.

56. Sampayo-Reyes, A., Zakharyan, R. A., Healy, S. M., and Aposhian, H. V. (2000). Monomethylarsonic acid reductase and monomethylarsonous acid in hamster tissue. Chem. Res. Toxicol. 13, 1181-1186.

57. Shuprisha, A., Lynch, R. M., Wright, S. H., and Dantzler, W. H. (2000). PKC regulation of organic anion secretion in perfused S2 segments of rabbit proximal tubules. Am. J. Physiol. Renal Physiol. 278, F104-F109.

58. Shuprisha, A., Wright, S. H., and Dantzler, W. H. (2000). Method for measuring luminal efflux of fluorescent organic compounds in isolated, perfused renal tubules. Am. J. Physiol. (Renal Physiol.) 279, F960-F964.

59. Stevens, G. J., Burkey, J. L., and McQueen, C. A. (2000). In vitro biotransformation and toxicity of the heterocyclic amine batracylin. Cell Biol. Toxicol. 16, 31-39.

60. Boyer, A. S. and Runyan, R. B. (2001). TGF? Type III and TGF? Type II receptors have distinct activities during epithelial-mesenchymal cell transformation in the embryonic heart. Dev. Dyn. 221, 454-459.

61. Catania, J. M., Parrish, A. R., and Gandolfi, A. J. (2001). Toxicity of a sevoflurane degradation product incubated with rat liver and renal cortical slices. Drug Chem. Toxicol. 24, 347-357.

62. Devine, P. J., Sipes, I. G., and Hoyer, P. B. (2001). Effect of 4-vinylcyclohexene diepoxide dosing in rats on GSH levels in liver and ovaries. Toxicol. Sci. 62, 315-320.

63. *Diawaraa, M. M., Chavez, K. J., Simpleman, D., Williams, D. E., Franklin, M. R., and Hoyer, P. B. (2001). The psoralens adversely affect reproductive function in male wistar rats. Reprod. Toxicol. 15, 137-144.

64. Fontaine, S. M., Mash, E. A., Hoyer, P. B., and Sipes, I. G. (2001). Stereochemical aspects of vinylcyclohexene bioactivation in rodent hepatic microsomes and purified human cytochrome P450 enzyme systems. Drug Metab. Dispos. 29, 179-184.

65. Fontaine, S. M., Hoyer, P. B., and Sipes, I. G. (2001). Evaluation of hepatic cytochrome P4502E1 in the species-dependent bioactivation of 4-vinylcclohexene. Life Sci. 69, 923-934.

66. Fontaine, S. M., Hoyer, P. B., Halpert, J. R., and Sipes, I. G. (2001). Role of Induction of Specific Hepatic cytochrome P450 isoforms in Epoxidation of 4-vinylcyclohexene. Drug Metab. Dispos. 29, 1236-1242.

67. Hoyer, P. B., Devine, P. J., Hu, X., Thompson, K. E., and Sipes, I. G. (2001). Ovarian toxicity of 4-vinylcyclohexene diepoxide: a mechanistic model. Toxicol. Pathol. 29, 91-99.

68. *Hoyer, P. B. (2001). Reproductive toxicology: current and future directions(1). Biochem. Pharmacol. 62, 1557-1564.

69. Hoyer, P. B., Cannady, E. A., Kroeger, N. A., and Sipes, I. G. (2001). Mechanisms of ovotoxicity induced by environmental chemicals: 4- vinylcyclohexene diepoxide as a model chemical. Adv. Exp. Med. Biol. 500 , 73-81.

70. Hu, X., Christian, P. J., Thompson, K. E., Sipes, I. G., and Hoyer, P. B. (2001). Apoptosis induced in rats by 4-vinylcyclohexene diepoxide is associated with activation of the caspase cascades. Biol. Reprod. 65, 87-93.

71. Hu, X., Christian, P., Sipes, I. G., and Hoyer, P. B. (2001). Expression and redistribution of cellular Bad, Bax, and Bcl-X(L) protein is associated with VCD-induced ovotoxicity in rats. Biol. Reprod. 65, 1489-1495.

72. *Islinger, F., Gekle, M., and Wright, S. H. (2001). Interaction of 2,3-dimercapto-1-propane sulfonate with the human organic anion transporter, hOAT1. J. Pharmacol. Exp. Ther. 299, 741-747.

73. Petrick, J. S., Jagadish, B., Mash, E. A., and Aposhian, H. V. (2001). Monomethylarsonous acid (MMAIII) and arsenite: ld(50) in hamsters and in vitro inhibition of pyruvate dehydrogenase. Chem. Res. Toxicol. 14, 651-656.

74. Wijeweera, J. B., Gandolfi, A. J., Parrish, A., and Lantz, R. C. (2001). Sodium arsenite enhances AP-1 and NFkappaB DNA binding and induces stress protein expression in precision-cut rat lung slices. Toxicol. Sci. 61, 283-294.

75. Zakharyan, R. A., Sampayo-Reyes, A., Healy, S. M., Tsaprailis, G., Board, P. G., Liebler, D. C., and Aposhian, H. V. (2001). Human monomethylarsonic acid (MMA(V)) reductase is a member of the glutathione-S-transferase superfamily. Chem. Res. Toxicol. 14, 1051-1057.

76. *Adams, D. G., Sachs, N.A., and Vaillancourt, R. R. (2002). Phosphorylation of the stress-activated protein kinase, MEKK2, at serine 166. Arch. Biochem. Biophys. 407:103-116.

77. *Bahn, A., Knabe, M., Hagos, Y., Rodiger, M., Godehardt, S., Graber-Neufeld, D. S., Evans, K. K., Burckhardt, G., and Wright, S. H. (2002). Interaction of the metal chelator, 2,3-dimercapto-1-propane sulfonate, with the rabbit multispecific organic anion transport 1 (rbOAT1). Mol. Pharmacol. 62, 1129-1136.

78. *Barendt, W. M. and Wright, S. H. (2002). The Human Organic Cation Transporter (hOCT2) Recognizes the Degree of Substrate Ionization. J. Biol. Chem. 277, 22491-22496.

79. *Borgeest, C., Symonds, D., Mayer, L. P., Hoyer, P. B., and Flaws, J. A. (2002). Methoxychlor may cause ovarian follicular atresia and proliferation of the ovarian epithelium in the mouse. Toxicol. Sci. 68, 473-478.

80. *Burckhardt, B. C., Drinkuth, B., Menzel, C., Konig, A., Steffgen, J., Wright, S. H., and Burckhardt, G. (2002). The renal Na+-dependent dicarboxylate transporter, NaDDC-3, translocates dimethyl-and disulfhydryl-compounds and contributes to renal heavy metal detoxification. J. Am. Soc. Nephrol. 13, 2628-2638.

81. Cannady, E. A., Sipes, I. G., and Hoyer, P. B. (2002). Expression and activity of microsomal epoxide hydrolase in follicles isolated from mouse ovaries. Toxicol. Sci. 68, 24-31.

82. *Dantzler, W. H. (2002). Renal Organic Anion Transport: A Comparative and Cellular Perspective. BBA-Biomembranes 1566, 169-181.

83. Devine, P. J., Sipes, I. G., Skinner, M. K., and Hoyer, P. B. (2002). Characterization of a Rat in vitro Ovarian Culture System to Study the Ovarian Toxicant 4-Vinylcyclohexene Diepoxide. Toxicol. Appl. Pharmacol. 184, 107-115.

84. *Erickson, R. P., Kiela, M., Devine, P. J., and Hoyer, P. B. (2002). mdr1a deficiency corrects sterility in Niemann-Pick C1 protein deficient female mice. Mol. Reprod. Dev. 62, 167-173.

85. *Gong, Z., Jiang, G., Cullen, W. R., Aposhian, H. V., and Le, X. C. (2002). Determination of Arsenic Metabolic Complex Excreted in Human Urine after Administration of Sodium 2,3-Dimercapto-1-propane Sulfonate. Chem. Res. Toxicol. 15, 1318-1323.

86. Hu, X., Flaws, J. A., Sipes, I. G., and Hoyer, P. B. (2002). Activation of mitogen-activated protein kinases and AP-1 transcription factor in ovotoxicity induced by 4-vinylcyclohexene diepoxide in rats. Biol. Reprod. 67, 718-724.

87. *Lazarus, R., Vercelli, D., Palmer, L. J., Klimecki, W. T., Silverman, E. K., Richter, B., Riva, A., Ramoni, M., Martinez, F. D., Weiss, S. T., and Kwiatkowski, D. J. (2002). Single nucleotide polymorphisms in innate immunity genes: abundant variation and potential role in complex human disease. Immunol. Rev. 190, 9-25.

88. Li, Y., Carter, D. E., and Mash, E. A. (2002). Synthesis and Structure of the Glutathione Conjugate of Chloroacetaldehyde. Synth. Commun. 32, 1579-1583.

89. Liu, J., Zheng, B., Aposhian, H. V., Zhou, Y., Chen, M. L., Zhang, A., and Waalkes, M. P. (2002). Chronic arsenic poisoning from burning high-arsenic-containing coal in Guizhou, China. Environ. Health Perspect. 110, 119-122.

90. Mayer, L. P., Pearsall, N. A., Christian, P. J., Devine, P. J., Payne, C. M., McCuskey, M. K., Marion, S. L., Sipes, I. G., and Hoyer, P. B. (2002). Long-term effects of ovarian follicular depletion in rats by 4-vinylcyclohexene diepoxide. Reprod. Toxicol. 16, 775-781.

91. Pannabecker, T. L., Brokl, O. H., Kim, Y. K., Abbott, D. E., and Dantzler, W. H. (2002). Regulation of intracellular pH in rat renal inner medullary thin limbs of Henle's loop. Pflugers Arch. 443, 446-457.

92. Parrish, A. R., Sallam, K., Nyman, D. W., Orozco, J., Cress, A. E., Dalkin, B. L., Nagle, R. B., and Gandolfi, A. J. (2002). Culturing precision-cut human prostate slices as an in vitro model of prostate pathobiology. Cell Biol. Toxicol. 18, 205-219.

93. *Raby, B. A., Klimecki, W. T., Laprise, C., Lemire, M., Greenwood, C., Weiland, K. M., Lange, C., Palmer, L. J., Lazarus, R., Vercelli, D., Kwiatkowski, D. J., Silverman, E. K., Martinez, F. D., Hudson, T. J., and Weiss, S. T. (2002). Polymorphisms in Toll-like Receptor 4 are not associated with asthma or atopy-related phenotypes. Am. J. Respir. Crit. Care Med. 166, 1449-1456.

94. Radabaugh, T. R., Sampayo-Reyes, A., Zakharyan, R. A., and Aposhian, H. V. (2002). Arsenate Reductase II. Purine Nucleoside Phosphorylase in the Presence of Dihydrolipoic Acid Is a Route for Reduction of Arsenate to Arsenite in Mammalian Systems. Chem. Res. Toxicol. 15, 692-698.

95. *Sipes, I. G., McQueen, C. A., and Gandolfi, A. J. (2002). Cellular and Molecular Toxicology. In: Comprehensive Toxicology (Vanden, Heuvel, Greenlee, Perdew, and Maltes, Eds.), Vol. 14, p. 644 pages. Elsevier-Academic Press.

96. Thompson, K. E., Sipes, I. G., Greenstein, B. D., and Hoyer, P. B. (2002). 17?-estradiol affords protection against 4-vinylcyclohexene diepoxide-induced ovarian follicle loss in Fischer-344 rats. Endocrinology 143, 1058-1065.

97. *Zhang, X., Evans, K. K., and Wright, S. H. (2002). Molecular cloning of rabbit organic cation transporter rbOCT2 and functional comparisons with rbOCT1. Am. J. Physiol. Renal Physiol. 283, F124-F133.

98. *Aposhian, H. V., Morgan, D. L., Queen, H. L., Maiorino, R. M., and Aposhian, M. M. (2003). Vitamin C, glutathione, or lipoic acid did not decrease brain or kidney mercury in rats exposed to mercury vapor. J. Toxicol. Clin. Toxicol. 41, 339-347.

99. Bednarczyk, D., Ekins, S., Wikel, J. H., and Wright, S. H. (2003). Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Mol. Pharmacol. 63, 489-498.

100. Begay, C. K. and Gandolfi, A. J. (2003). Late administration of COX-2 inhibitors minimize hepatic necrosis in chloroform induced liver injury. Toxicology 185, 79-87.

101. Cannady, E. A., Dyer, C. A., Christian, P. J., Sipes, I. G., and Hoyer, P. B. (2003). Expression and activity of cytochromes P450 2E1, 2A, and 2B in the mouse ovary: the effect of 4-vinylcyclohexene and its diepoxide metabolite. Toxicol. Sci.. 73, 423-430.

102. *Carter, D. E., Aposhian, H. V., and Gandolfi, A. J. (2003). The metabolism of inorganic arsenic oxides, gallium arsenide, and arsine: a toxicochemical review. Toxicol. Appl. Pharmacol. 193, 309-334.

103. Catania, J. M., Parrish, A. R., Kirkpatrick, D. S., Chitkara, M., Bowden, G. T., Henderson, C. J., Wolf, C. R., Clark, A. J., Brendel, K., Fisher, R. L., and Gandolfi, A. J. (2003). Precision-cut tissue slices from transgenic mice as an in vitro toxicology system. Toxicol In vitro 17, 201-205.

104. *Choudhuri, S., Cherrington, N. J., Li, N., and Klaassen, C. D. (2003). Constitutive Expression of various xenobiotic and endobiotic transporter mRNA in the choroids plexus of adult Sprague-Dawley rats. Drug Metab. Dispos. 31, 1337-1345.

105. *Collier, J. M., Cover, C. C., Selmin, O., Johnson, P. D., and Runyan, R. B. (2003). Trichloroethylene effects on gene expression. Birth Defects Research 67, 488-495.

106. Groves, C. E., Munoz, L., Bahn, A., Burckhardt, G., and Wright, S. H. (2003). Interaction of cysteine conjugates with human and rabbit organic anion transporter 1. J. Pharmacol. Exp. Ther. 304, 560-566.

107. Jagadish, B., Aposhian, H. V., and Mash, E. A. (2003). An Efficient Synthesis of Sodium Dimethylarsenate-14C. J. Labelled Compounds and Radiopharmaceuticals 46, 373-377.

108. Kirkpatrick, D. S., Dale, K. V., Catania, J. M., and Gandolfi, A. J. (2003). Low-level arsenite causes accumulation of ubiquitinated proteins in rabbit renal cortical slices and HEK293 cells. Toxicol. Appl. Pharmacol. 186, 101-109.

109. *Lazarus, R., Klimecki, W. T., Raby, B. A., Vercelli, D., Palmer, L. J., Kwiatkowski, D. J., Silverman, E. K., Martinez, F., and Weiss, S. T. (2003). Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U. S. ethnic groups and exploratory case-control disease association studies (small star, filled). Genomics 81, 85-91.

110. *Loffredo, C. A., Aposhian, H. V., Cebrian, M. E., Yamauchi, H., and Silbergeld, E. K. (2003). Variability in human metabolism of arsenic. Environ. Res 92, 85-91.

111. McQueen, C. A., Mitchell, M. K., Dang, L. N., Chau, B., Tjalkens, R. B., and Philbert, M. A. (2003). Prenatal expression of N-acetyltransferases in C57Bl/6 mice. Chem. Biol. Interact. 145, 77-87.

112. *McQueen, C. A., Chau, B., Erickson, R. P., Tjalkens, R. B., and Philbert, M. A. (2003). The effects of genetic variation in N-Acetyltransferases on 4-aminobiphenyl genotoxicity in mouse liver. Chem. Biol. Interact. 146, 51-60.

113. McQueen, C. A. and Chau, B. (2003). Neonatal ontogeny of murine arylamine N-acetyltransferases: implications for arylamine genotoxicity. Toxicol. Sci. 73, 279-286.

114. Sachs, N. A. and Vaillancourt, R. R. (2003) Cyclin-Dependent 11(p110) Activity in the Absence of CK2. Biochem. Et. BioPhys. Acta. 162(1-3):98-108.

115. Shi, J., Feng, Y., Goulet, A. C., Vaillancourt, R. R., Sachs, N. A., Hershey, J. W., and Nelson, M. A. (2003). The p34cdc2-related cyclin-dependent kinase 11 interacts with the
p47 subunit of eukaryotic initiation factor 3 during apoptosis. J. Biol. Chem. 278, 5062-5071.

116. Zheng, X. H., Watts, G. S., Vaught, S., and Gandolfi, A. J. (2003). Low-level arsenite induced gene expression in HEK293 cells. Toxicology 187, 39-48.

117. *Aposhian, H. V., Zakharyan, R. A., Healy, S. M., Wildfang, E., Petrick, J. S., Sampayo-Reyes, A., Board, P. G., Carter, D. E., Guhu Mazumder, D. N., and Aposhian, M. M. (2004). Enzymology and Toxicity of Inorganic Arsenic. In: Arsenic Exposure and Health Effects V. (W. R. Chappel, C. O. Abernathy, and R. L. Calderon, Eds.), Elsevier Scientific Ltd.

118. *Derbyshire, Z. E., Halfter, U. M., Heimark, R. L., and Vaillancourt, R. R. (2004) Angiotensin II stimulated transcription of cyclooxygenase II is regulated by a novel kinase cascade involving Pyk2, MEKK4 and annexin II. Mol. Cell. Biol., Submitted.

119. *Kaewmokul, S., Chatsudthipong, V., Evans, K. K., Dantzler, W. H., and Wright, S. H. (2004). Functional Mappig of rbOCT1 and rbOCT2 Activity in the S2 Segment of Rabbit Proximal Tubule. Am. J. Physiol. (Renal Physiol.), In Press.

120. Kirkpatrick, D. D., Weldon, S. F., Tsaprailis, G., Liebler, D. C., and Gandolfi, A. J. (2004). Qualitative and quantitative analysis of charges in the ubiquitin pathway in human cells using LC-MS/MS. Mol. Cell. Proteomics, Submitted.

121. *Lungkaphin, A., Chatsudthipong, V., Evans, K. K., Groves, C. E., Wright, S. H., and Dantzler, W. H. (2004). Interaction of the Metal Chelator, DMPS, with OAT1 and OAT3 in Intact Isolated Rabbit Renal Proximal Tubules. Am. J. Physiol. (Renal Physiol.), In Press.

122. Nyman, D., Marshall, J., Nagle, R. B., and Gandolfi, A. J. (2004). Selenium and selenomethione levels in prostate cancer patients. Cancer Detect. And Prevent., In Press.

123. *Peraza, M. A., Carter, D. E., and Gandolfi, A. J. (2004). Toxicity and metabolism of subcytotoxic inorganic arsenic in human renal proximal tubule epithelial cells (HK-2). Cell Biol Toxicol 19, 253-264.

124. *Scott, N., Gufang Z., Aposhian, H. V., and Carter, D. E. (2004). Mass spectrometry of toxicologically significant arsenic-thiol species. Chem. Res. Toxicol., Submitted.

Publications related to Center theme and/or productivity:

125. Aposhian, H. V., Ingersoll, R. T., and Montgomery, E. B. J. (1999). Transport and control of manganese ions in the central nervous system. Environ. Res. 80, 96-98.

126. Ayala-Fierro, F., Firriolo, J. M., and Carter, D. E. (1999). Disposition, toxicity, and intestinal absorption of cobaltous chloride in male Fischer 344 rats. J. Toxicol. Environ. Health A 56, 571-591.

127. Boyer, A. S., Erickson, C. P., and Runyan, R. B. (1999). Epithelial-mesenchymal transformation in the embryonic heart is mediated through distinct pertussis toxin-sensitive and TGF?signal transduction mechanisms. Dev. Dyn. 214, 81-91.

128. Boyer, A. S., Ayerinskas, I. I., Vincent, E. B., McKinney, L. A., Weeks, D. L., and Runyan, R. B. (1999). TGF?2 and TGF?3 have separate and sequential activities during epithelial-mesenchymal cell transformation in the embryonic heart. Dev. Biol. 208, 530-545.

129. Brokl, O. H., Martinez, C. L., Kim, Y. K., Abbott, D. E., and Dantzler, W. H. (1999). Basolateral regulation of pHi in proximal tubules of avian loopless and long-looped nephrons in bicarbonate. J. Exp. Zool. 284, 174-187.

130. Brown, C. B., Boyer, A. S., Runyan, R. B., and Barnett, J. V. (1999). Requirement of type III TGF-? receptor for endocardial cell transformation in the heart. Science 283, 2080-2082.

131. Dantzler, W. H. (1999). Transport of organic molecules by reprilian nephrons. J. Exp. Zool .283, 675-688.

132. Dantzler, W. H., Serrano, O. K., Abbott, D. E., Kim, Y. K., and Brokl, O. H. (1999). Basolateral regulation of pHi in isolated snake renal proximal tubules in presence and absence of bicarbonate. Am. J. Physiol. 276, R1673-R1681.

133. Raghunand, N., Martinez-Zaguilan, R., Wright, S. H., and Gillies, R. J. (1999). PH and drug resistance. II. Turnover of acidic vesicles and resistance to weakly basic chemotherapeutics. Biochem. Pharmacol. 57, 1047-1058.

134. Romano, L. A. and Runyan, R. B. (1999). Slug is a mediator of epithelial-mesenchymal cell transformation in the developing chicken heart. Dev. Biol. 212, 243-254.

135. Silbernagl, S., Volker, K., and Dantzler, W. H. (1999). D-Serine is reabsorbed in rat renal pars recta. Am. J. Physiol. 276, F857-F863.

136. Zakharyan, R. A., Ayala-Fierro, F., Cullen, W. R., Carter, D. E., and Aposhian, H. V. (1999). Enzymatic methylation of arsenic compounds. VII. Monomethylarsonous acid (MMAIII) is the substrate for MMA methyltransferase of rabbit liver and human hepatocytes. Toxicol. Appl. Pharmacol. 158, 9-15.

137. Boyer, A.S. and Runyan, R.B. (2000). TGFb signal transduction during heart valve development. In: Heart Development (R. Tomanek and R.B. Runyan, Eds.), JAI Press, Stanford, CT.

138. Diawara, M.M., Hoyer, P.B., Chavez, K.J., and Williams, D.E. (2000). 8-Methoxypsoralen (xanthotoxin or methoxsalen) compromises ovarian follicle development in rats. In: Dietary Anticarcinogenes and Mutagens: Chemical and Biological Aspects (I.T. Johnson and G.R. Fenwick, Eds.), pp. 361-365. Royal Society of Chemistry, Cambridge.

139. Hein, D. W., McQueen, C. A., Grant, D. M., Goodfellow, G. N., Kadlubar, F. F., and Weber, W. W. (2000). Pharmacogenetics of the arylamine N-acetyltransferases: A symposium in honor of Wendell W. Weber. Drug Metab. Dispos. 28, 1425-1432.

140. Hoyer, P.B. and Devine, P.J. (2000). Endocrinology and Toxicology: The Female Reproductive System. In Handbook of Toxicology CRC Press.

141. Pummer, S., Dantzler, W. H., Lien, Y. H., Moeckel, G. W., Volker, K., and Silbernagl, S. (2000). Reabsorption of betaine in Henle's loops of rat kidney in vivo. Am. J. Physiol. Renal. Physiol. 278, F434-F439.

142. Romano, L. A. and Runyan, R. B. (2000). Slug is an essential target of TGF? 2 signaling in the developing chicken heart. Dev. Biol. 223, 91-102.

143. Varady, R. G., Arnold, R. G., Carter, D. E., Guzman, R., Pena, C., and Suk, W. A. (2000). Hazardous Waste and the U.S.-Mexico Border Region: Toward a Binational, University-based Institution. Environmental Practices, March.

144. Fisher, R. L., Gandolfi, A. J., and Brendel, K. (2001). Human liver quality is a dominant factor in the outcome of in vitro studies. Cell Biol. Toxicol. 17, 179-189.

145. McQueen, C.A. (2001). Arylamine N-acetyltransferases. In Current Protocols in Toxicology (L.G. Costa, M.D. Maines, D.J. Reed, S. Sassa, and I.G. Sipes, Eds.), p. 4.6.1-4.6.13. John Wiley and Sons, New York.

146. Okeson, C. D. and Riley, M. R. (2001). Glutamine replenishment and ammonia removal in hybridoma cell cultures via immobilized glutamine synthetase. Biochemical Engineering Journal 9, 125-133.

147. Zheng, X. H., Begay, C., Lind, R. C., and Gandolfi, A. J. (2001). Humoral immune response to A sevoflurane degradation product in the guinea pig following inhalation exposure. Drug Chem. Toxicol. 24, 339-346.

148. Camenisch, T. D., Molin, D. G., Person, A., Runyan, R. B., Gittenberger-de Groot, A. C., McDonald, J. A., and Klewer, S. E. (2002). Temporal and distinct TGF? ligand requirements during mouse and avian endocardial cushion morphogenesis. Dev. Biol. 248, 170-181.

149. Devine, P. J., Rajapaksa, K. S., and Hoyer, P. B. (2002). In vitro ovarian tissue and organ culture: a review. Front Biosci. 7, d1979-d1989.

150. Fisher, R. L., Hasal, S. J., Lipscomb, J. C., Gandolfi, A. J., and Brendel, K. (2002). Cold- and cryopreservation of monkey liver slices. Toxicology Mechanisms Methods 12, 119-133.

151. Tran, N. L., Adams, D. G., Vaillancourt, R. R., and Heimark, R. L. (2002). Signal transduction from N-cadherin increases Bcl-2. Regulation of the phosphatidylinositol 3-kinase/Akt pathway by homophilic adhesion and actin cytoskeletal organization. J. Biol. Chem. 277, 32905-32914.

152. Buist, S. C. N., Cherrington, N. J., and Klaassen, C. D. (2003). Endocrine regulation of rat organic anion transporters. Drug Metab. Dispos. 31, 559-564.

153. Cherrington, N. J., Slitt, A. L., Maher, J. M., Zhang, X. X., Zhang, J., Huang, W., Wan, Y., Moore, D. D., and Klaassen, C. D. (2003). Induction of multidrug resistance protein 3 (Mrp3) in vivo is independent of constitutive androstane receptor. Drug Metab. Dispos. 31, 1315-1319.

154. Kirkpatrick, D.L. and Gandolfi, A.J. (2003). In vitro techniques in screening and mechanistic studies: organ perfusion, slices, and nephron components. In: Toxicology and the Kidney (L.H. Lash and J.B. Tarloff, Eds.), p. 40 pages.

155. Meza, M., Kopplin, M., and Gandolfi, A. J. Arsenic drinking water exposure and urinaty excretion among adults in the Yaqui Valley, Sonora, Mexico. Environ. Res. 2003.

156. Quanrud, D. M., Arnold, R. G., Lansey, K. E., Begay, C. K., Ela, W., and Gandolfi, A. J. (2003). Fate of effluent organic matter during soil aquifer treatment: biodegradability, chlorine reactivity, and genotoxicity. J. Water and Health 1, 33-44.

157. Shelby, M. K., Cherrington, N. J., Vansel, N. R., and Klaassen, C. D. (2003). Tissue mRNA expression of the rat UDP-Glucuronosltransferase gene family. Drug Metab. Dispos. 31, 326-333.

158. Silbernagl, S., Volker, K., and Dantzler, W. H. (2003). Tubular reabsorption of myo-inositol vs. that of D-glucose in rat kidney in vivo et situ. Am. J. Physiol. Renal Physiol. 284, F1181-F1189.

159. Yu, L., Kalla, K., Guthrie, E., Vidrine, A., and Klimecki, W. T. (2003). Genetic variation in arsenic metabolizing genes: GST-Omega and Purine Nucleoside Phosphorylase polymorephisms in European and Indigenous Americans. Environ. Health Perspect. Toxicogenomics 111, 1421-1428.

160. Bredfeldt, T. G., Kirkpatrick, D. S., Kopplin, M., and Gandolfi, A. J. (2004) Effect of low-level arsenite exposure on UROsta cells. Production of ubiquinated proteins and stimulation by BSO. Toxicol. Appl. Pharmacol., In Press.

161. Rose, R. L., Tang, J., Coi, J., Cao, Y., Usmani, A., and Cherrington, N. J. (2004) Pesticide metabolism in humans, including polymorphisms. Scan. J. Work Environ. Health, In Press.