Southwest Environmental Health Sciences Center Pulmonary Toxicology and Lung Disease Home Page

Pulmonary Toxicology and Lung Disease Research Core

The Pulmonary Toxicology and Lung Disease Research Core promotes interdisciplinary research into the mechanisms by which environmental agents affect lung function and lead to, or exacerbate, disease.

The current goal of the Pulmonary Toxicology and Lung Disease Research Core is to strengthen research into the effects of toxicants on the lung. The specific objective of the Pulmonary Toxicology and Lung Disease Research Core is to promote interdisciplinary research into the mechanisms by which environmental agents affect lung function and lead to, or exacerbate, disease. In addition, the Core serves as a resource to other SWEHSC investigators for assistance with problems involving research in pulmonary toxicology. Four Specific Research Themes have evolved, based on input from the members of the Research Core. These are research on:

1. Pulmonary responses to complex mixtures
2. Pulmonary responses to inhalation of jet fuel
3. Pulmonary responses to arsenicals
4. Model systems for testing pulmonary toxic responses

The Pulmonary Toxicology and Lung Disease Research Core consists of six investigators representing three colleges (Medicine, Public Health, and Agriculture) and the Departments of Physiology, Environmental and Occupational Health, Cell Biology and Anatomy, Surgery, Agriculture and Biosystems Engineering, and Pediatrics and the Arizona Respiratory Center.

Recent publications by members of the core. For a complete list of publications click here.

2004

Riley, M. R., Jordan, K. A., Boesewetter, D. E., Cox, M. L., and Kim, A. M. (2004) Development of a cell-based biosensor to evaluate the toxicity of inhaled materials. Biochem. Engr. J., In Press.

2003

Boonmung, S. and Riley, M. R. (2003). Quantitative analysis of added ammonium and nitrate in silica sand using diffuse reflectance infared spectroscopy. Spectroscopy Letters 36, 251-274.

Burgess, J. L., Witten, M. L., Nanson, C. J., Hysong, T. A., Sherrill, D. L., Quan, S. F., Gerkin, R., and Bernard, A. M. (2003). Serum pneumoproteins: a cross-sectional comparison of firefighters and police. Am. J. Ind. Med. 44, 246-253.

Hays, A. M., Lantz, R. C., and Witten, M. L. (2003). Correlation between in vivo and in vitro pulmonary responses to jet propulsion fuel-8 using precision-cut lung slices and a dynamic organ culture system. Toxicol. Pathol. 31, 200-207.

Hysong, T. A., Burgess, J. L., Cebrian Garcia, M. E., and O'Rourke, M. K. (2003). House dust and inorganic urinary arsenic in two Arizona mining towns. J. Expo. Anal. Environ. Epidemiol. 13, 211-218.

Isakson, B. E., Seedorf, G. J., Lubman, R., Evans, W. H., and Boitano, S. (2003). Cell-Cell communication in heterocellular cultures of alveolar epithelial cells. Am. J. Resp. Cell. and Mol. Biol. 29, 552-561.

Lantz, R. C., Orozco, J., and Bogdanffy, M. S. (2003). Vinyl acetate decreases intracellular pH in rat nasal epithelial cells. Toxicol. Sci. 75, 423-431.

Riley, M. R., Boesewetter, D. E., Kim, A. M., and Sirvent, F. P. (2003). Effects of metals Cu, Fe, Ni, V, and Zn on rat lung epithelial cells. Toxicology 190, 171-185.

Links to our current news from the Research Core:

SWEHSC Center for Toxicology University of Arizona TOP

Southwest Environmental Health Sciences Center University of Arizona College of Pharmacy, Room 244 PO Box 210207, Tucson, AZ, USA 85721-0207 swehsc-info@pharmacy.arizona.edu 520-626-5594 520-626-6944(FAX)	*Funded by NIEHS grant # ES06694*

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