Publications of Research Core 3 Investigators, 1999-2004.
Printable List of Publications in .pdf format

1. *Broome, P. M., Gause, P. R., Hyman, P., Gregus, J., Lluria-Prevatt, M., Nagle, R., and Bowden, G. T. (1999). Induction of melanoma in TPras transgenic mice. Carcinogenesis 20, 1747-1753.

2. Chen, W. and Bowden, G. T. (1999). Activation of p38 MAP kinase and ERK are required for ultraviolet-B induced c-fos gene expression in human keratinocytes. Oncogene 18, 7469-7476.

3. Chen, W., Dong, Z., Valcic, S., Timmermann, B. N., and Bowden, G. T. (1999). Inhibition of ultraviolet B--induced c-fos gene expression and p38 mitogen-activated protein kinase activation by (-)-epigallocatechin gallate in a human keratinocyte cell line. Mol. Carcinog. 24, 79-84.

4. *Einspahr, J. G., Alberts, D. S., Warneke, J. A., Bozzo, P., Basye, J., Grogan, T. M., Nelson, M. A., and Bowden, G. T. (1999). Relationship of p53 mutations to epidermal cell proliferation and apoptosis in human UV-induced skin carcinogenesis. Neoplasia. 1, 468-475.

5. Gupta, A., Rosenberger, S. F., and Bowden, G. T. (1999). Increased ROS levels contribute to elevated transcription factor and MAP kinase activities in malignantly progressed mouse keratinocyte cell lines. Carcinogenesis 20, 2063-2073.

6. Gupta, A., Andrews, K. L., McDaniel, K. M., Nagle, R. B., and Bowden, G. T. (1999). Experimental induction of rhabdomyosarcoma in mice with fractionated doses of ?-irradiation. J. Cancer Res. Clin. Oncol. 125, 257-267.

7. Jeffy, B. D., Schultz, E. U., Selmin, O., Gudas, J. M., Bowden, G. T., and Romagnolo, D. (1999). Inhibition of BRCA-1 expression by benzo[a]pyrene and its diol epoxide. Mol. Carcinog. 26, 100-118.

8. *Klein, R. D., Maliner-Jongewaard, M. S., Udayakumar, T. S., Boyd, J. L., Nagle, R. B., and Bowden, G. T. (1999). Promatrilysin expression is induced by fibroblast growth factors in the prostatic carcinoma cell line LNCaP but not in normal primary prostate epithelial cells. Prostate 41, 215-223.

9. *Kramer-Stickland, K., Edmonds, A., Bair, W. B., and Bowden, G. T. (1999). Inhibitory effects of deferoxamine in UVB-induced AP-1 transactivation. Carcinogenesis 20, 2137-2142.

10. Milczarek, G. J., Gupta, A., Martinez, J. D., and Bowden, G. T. (1999). Okadaic acid mediates p53 hyperphosphorylation and growth arrest in cells with wild type p53 but increases aberrant mitoses in cells with non-functional p53. Carcinogenesis 20, 1043-1048.

11. Mitchell, M. K., Futscher, B. W., and McQueen, C. A. (1999). Developmental expression of N-acetyltransferases in C57BI/6 mice. Drug Metab. Dispos. 27, 261-264.

12. *Rosenberger, S. F., Finch, J. S., Gupta, A., and Bowden, G. T. (1999). Extracellular signal-regulated kinase 1/2-mediated phosphorylation of JunD and FosB is required for okadaic acid-induced activator protein 1 activation. J. Biol. Chem. 274, 1124-1130.

13. Rosenberger, S. F., Gupta, A., and Bowden, G. T. (1999). Inhibition of p38 MAP kinase increases okadaic acid mediated AP-1 expression and DNA binding but has no effect on TRE dependent transcription. Oncogene 18, 3626-3632.

14. *Sundareshan, P., Nagle, R. B., and Bowden, G. T. (1999). EGF induces the expression of matrilysin in the human prostate adenocarcinoma cell line, LNCaP. Prostate 40, 159-166.

15. *Chen, Q. M., Tu, V. C., Wu, Y. W., and Bahl, J. J. (2000). Hydrogen Peroxide Dose Dependent Induction of Hypertrophy or Apoptosis of Rat Cardiomyocytes. Arch. Biophys. Biochem. 373, 242-248.

16. *Chen, Q. M., Liu, J., and Merrett, J. B. (2000). Apoptosis or senescence-like growth arrest: influence of cell-cycle position, p52, p21 and bax in H2O2 response of normal human fibroblasts. Biochem. J. 347, 543-551.

17. *Chen, Q. M. (2000). Replicative senescence and oxidant-induced premature senescence. Beyond the control of cell cycle checkpoints. Ann. N. Y. Acad. Sci. 908, 111-125.

18. *Chen, Q. M., Liu, J. P., and Tu, V. C. (2000). Measurements of Hydrogen Peroxide Induced Premature Senescence: Senscence-Associated B-galactosidase and DNA Synthesis Index in Human Diploid Fibroblaasts with Down-regulation p53 or Rb. Biogerontology 1, 335-339.

19. *Chen, Q. M., Tu, V. C., Catania, J. M., Burton, M., Toussaint, O., and Dilley, T. (2000). Involvement of Rb family proteins, focal adhesion proteins and protein synthesis in senescent morphogenesis induced by hydrogen peroxide. J. Cell Sci. 113, 4087-4097.

20. Chen, W. and Bowden, G. T. (2000). Role of p38 mitogen-activated protein kinases in ultraviolet-B irradiation-induced activator protein 1 activation in human keratinocytes. Mol. Carcinog. 28, 196-202.

21. *Domann, F. E., Rice, J. C., Hendrix, M. J., and Futscher, B. W. (2000). Epigenetic Silencing of the Maspin Gene in Human Brat Cancer Cells. Int. J. Cancer 85, 805-811.

22. *Dumont, P., Burton, M., Chen, Q. M., Gonos, E. S., Frippiat, C., Mazarati, J. B., Eliaers, F., Remacle, J., and Toussaint, O. (2000). Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast. Free Radic. Biol. Med. 28, 361-373.

23. *Jeffy, B. D., Chen, E. J., Gudas, J. M., and Romagnolo, D. F. (2000). Disruption of cell cycle kinetics by benzo[a]pyrene: inverse expression patterns of BRCA-1 and p53 in MCF-7 cells arrested in S and G2. Neoplasia 2, 460-470.

24. *Nomura, M., Ma, W. Y., Huang, C., Yang, C. S., Bowden, G. T., Miyamoto, K., and Dong, Z. (2000). Inhibition of ultraviolet B-induced AP-1 activation by theaflavins from black tea. Mol. Carcinog. 28, 148-155.

25. *Rice, J. C. and Futscher, B. W. (2000). Transcriptional repression of BRCA1 by aberrant cytosine methylation, histone hypoacetylation and chromatin condensation of the BRCA1 promoter. Nucleic Acids Research 28, 3233-3239.

26. *Rice, J. C., Ozcelik, H., Maxeiner, P., Andrulis, I., and Futscher, B. W. (2000). Methylation of the BRCA1 Promoter is Associated with Decreased Expression of BRCA1 Expression in Clinical Breast Cancer Specimens. Carcinogenesis 21, 1761-1765.

27. *Stevens, J. L., Liu, H., Halleck, M., Bowes, R. C. I., Chen, Q. M., and van de Water, B. (2000). Linking Gene Expression to Mechanisms of Toxicity. Toxicol. Lett. 112-113, 479-486.

28. *Calaluce, R., Kunkel, M. W., Watts, G. S., Schmelz, M., Hao, J., Barrera, J., Gleason-Guzman, M., Isett, R., Fitchmun, M., Bowden, G. T., Cress, A. E., Futscher, B. W., and Nagle, R. B. (2001). Laminin-5-mediated Gene Expression in Human Prostate Carcinoma Cells. Mol. Carcinog. 30, 119-129.

29. Chen, Q. M., Tu, V. C., Purdom, S., Wood, J., and Dilley, T. D. (2001). Molecular Mechanisms of Cardiac Hypertrophy Induced by Toxicants. Cardiovasc. Toxicol. 1, 267-283.

30. *Chen, Q. M., Prowse, K. R., Tu, V. C., Purdom, S., and Linskens, M. H. (2001). Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblasts. Exp. Cell Res. 265, 294-303.

31. Chen, W., Tang, Q., Gonzales, M. S., and Bowden, G. T. (2001). Role of p38 MAP kinases and ERK in mediating ultraviolet-B induced cyclooxygenase-2 gene expression in human keratinocytes. Oncogene 20, 3921-3926.

32. *Finch, J. S., Rosenberger, S. F., Martinez, J. D., and Bowden, G. T. (2001). Okadaic acid induces transcription of junB through a CCAAT box and NF-Y. Gene 267, 135-144.

33. *Frippiat, C., Chen, Q. M., Zdanov, S., Magalhaes, J. P., Remacle, J., and Toussaint, O. (2001). Subcytotoxic H2O2 stress triggers a release of transforming growth factor-? 1, which induces biomarkers of cellular senescence of human diploid fibroblasts. J. Biol. Chem. 276, 2531-2537.

34. *Gupta, A., Butts, B., Kwei, K. A., Dvorakova, K., Stratton, S. P., Briehl, M. M., and Bowden, G. T. (2001). Attenuation of catalase activity in the malignant phenotype plays a functional role in an in vitro model for tumor progression. Cancer Lett. 173, 115-125.

35. *Jacobson, E. L., Giacomoni, P. U., Roberts, M. J., Wondrak, G. T., and Jacobson, M. K. (2001). Optimizing the energy status of skin cells during solar radiation. J. Photochem. Photobiol. B 63, 141-147.

36. *Jacobson, E. L., Giacomoni, P. U., and Jacobson, M. K. (2001). Metabolic Effects of Solar Radiation and Enhancers of Energy Metabolism. In: Sun Protection in Man, Comprehensive Series in Photosciences pp. 677-690. European Society for Photobiology Press, Erlangen, Germany.

37. *Katschinski, D. M., Jacobson, E. L., Wiedemann, G. J., and Robins, H. I. (2001). Modulation of VP-16 Cytotoxicity by Carboplatin and 41. 8o C Hyperthermia. J. Cancer Res. Clin. Oncol. 127, 425-432.

38. Liebler, D. C., Valcic, S., Arora, A., Burr, J. A., Cornejo, S., Nair, M. G., and Timmermann, B. N. (2001). Antioxidant reactions of green tea catechins and soy isoflavons. In: Biological Reactive Intermediates IV. Chemical and Biological Mechanisms in Susceptibility to and Prevention of Environmental Diseases (P. M. Dansette, R. Snyder, M. Delaforge, G. G. Gibson, H. Greim, D. J. Jollow, T. J. Monks, and I. G. Sipes, Eds.), Vol. 500, pp. 191-197. Kluwer Academic/Plenum Publishers, New York.

39. Thompson, E. J., Gupta, A., Vielhauer, G. A., Regan, J. W., and Bowden, G. T. (2001). The growth of malignant keratinocytes depends on signaling through the PGE(2) receptor EP1. Neoplasia 3, 402-410.

40. *Watts, G. S., Futscher, B. W., Isett, R. B., Guzman, M., Kunkel, M. W., and Salmon, S. E. (2001). cDNA Microarray Analysis of Multidrug Resistance: Doxorubicin Selection Produces Multiple Defects in Apoptosis Signaling Pathways. J. Pharmacol. Exp. Ther. 299, 434-441.

41. *Zewail-Foote, M., Li, V. -S., Kohn, H., Bearss, D. J., Guzman, M., and Hurley, L. H. (2001). The inefficiency of incisions of ecteinascidin 743-DNA adducts by the UvrABC nuclease and the unique structural feature of the DNA adducts can be used to explain the repair-dependent toxicities of this antitumor agent. Chem. Biol. 8, 1033-1049.

42. *Zhou, Q., Duan, W., Simmons, D., Shayo, Y., Raymond, M. A., Dorr, R. T., and Hurley, L. H. (2001). Design and Synthesis of a Novel DNA-DNA Interstrand Adenine-Guanine Cross-Linking Agent. J. Am. Chem. Soc. 123, 4865-4866.

43. Bernstein, H., Holubec, H., Warneke, J. A., Garewal, H., Earnest, D. L., Payne, C. M., Roe, D. J., Cui, H., Jacobson, E. L., and Bernstein, C. (2002). Patchy field defects of apoptosis resistance and dedifferentiation in flat mucosa of colon resections from colon cancer patients. Ann. Surg. Oncol. 9, 505-517.

44. Chen, Q. M., Merrett, J. B., Dilley, T., and Purdom, S. (2002). Down regulation of p53 with HPV E6 delays and modifies cell death in oxidant response of human diploid fibroblasts: an apoptosis-like cell death associated with mitosis. Oncogene 21, 5313-5324.

45. *Chen, Q. M. and Tu, V. C. (2002). Apoptosis and Heart Failure: Mechanisms and Therapeutic Implications (commissioned review article). Am. J. Cardiovasc. Drugs 2, 43-57.

46. *Crowley-Weber, C. L., Payne, C. M., Gleason-Guzman, M., Watts, G. S., and Futscher, B. W. (2002). Development and molecular characterization of HCT-116 cell lines resistant to the tumor promoter and multiple stress-inducer, deoxycholate. Carcinogenesis 23, 2063-2080.

47. *Einspahr, J. G., Nelson, M. A., Saboda, K., Warneke, J., Bowden, G. T., and Alberts, D. S. (2002). Modulation of biologic endpoints by topical difluoromethylornithine (DFMO), in subjects at high-risk for nonmelanoma skin cancer. Clin. Cancer Res. 8, 149-155.

48. Finch, J., Joseloff, E., and Bowden, G. T. (2002). JunB negativity regulates Ap-1 activity and cell proliferation of malignant mouse keratinocytes. J. Cancer Res. Clin. Oncol. 128, 3-10.

49. *Futscher, B. W., Oshiro, M. M., Wozniak, R. J., Holtan, N., Hanigan, C. L., Duan, H., and Domann, F. E. (2002). Role for DNA methylation in the control of cell type specific maspin expression. Nat. Genet. 31, 175-179.

50. *Gonzales, M. and Bowden, G. T. (2002). Ultraviolet B (UVB) induction of the c-fos promoter is mediated by phospho-cAMP response element binding protein (CREB) binding to CRE and c-fos activator protein 1 site (FAP1) cis elements. Gene 293, 169-179.

51. *Gonzales, M. and Bowden, G. T. (2002). The role of PI 3-kinase in the UVB-induced expression of c-fos. Oncogene 21, 2721-2728.

52. *Gonzales, M. and Bowden, G. T. (2002). Nordihydroguaiaretic acid-mediated inhibition of ultraviolet B-induced activator protein-1 activation in human keratinocytes. Mol. Carcinog. 34, 102-111.

53. *Grand, C. L., Han, H., Munoz, R. M., Weitman, S., Von Hoff, D. D., Hurley, L. H., and Bearss, D. J. (2002). The Cationic Porphyrin TMPyP4 Downregulates c-MYC and hTERT Expression and Inhibits Tumor Growth in vivo. Molecular Cancer Therapeutics 1, 565-573.

54. Jeffy, B. D., Chirnomas, R. B., Chen, E. J., Gudas, J. M., and Romagnolo, D. F. (2002). Activation of the aromatic hydrocarbon receptor pathway is not sufficient for transcriptional repression of BRCA-1: requirements for metabolism of benzo[a]pyrene to 7r,8t-dihydroxy-9t,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene. Cancer Res. 62, 113-121.

55. Jeffy, B. D., Chirnomas, R. B., and Romagnolo, D. F. (2002). Epigenetics of breast cancer: polycyclic aromatic hydrocarbons as risk factors. Environ. Mol. Mutagen. 39, 235-244.

56. Thompson, E. J., MacGowan, J., Young, M. R., Colburn, N., and Bowden, G. T. (2002). A Dominant Negative c-jun Specifically Blocks Okadaic Acid-induced Skin Tumor Promotion. Cancer Res. 62, 3044-3047.

57. *Tu, V. C., Bahl, J. J., and Chen, Q. M. (2002). Signals of oxidant-induced cardiomyocyte hypertrophy: key activation of p70 S6 kinase-1 and phosphoinositide 3-kinase. J. Pharmacol. Exp. Ther. 300, 1101-1110.

58. *Wondrak, G. T., Cervantes-Laurean, D., Roberts, M. J., Qasem, J. G., Kim, M., Jacobson, E. L., and Jacobson, M. K. (2002). Identification of ?-dicarbonyl scavengers for cellular protection against carbonyl stress. Biochem. Pharmacol. 63, 361-373.

59. *Wondrak, G. T., Roberts, M. J., Jacobson, M. K., and Jacobson, E. L. (2002). Photosensitized growth inhibition of cultured human skin cells: mechanism and suppression of oxidative stress from solar irradiation of glycated proteins. J. Invest. Dermatol. 119, 489-498.

60. *Wondrak, G. T., Jacobson, E. L., and Jacobson, M. K. (2002). Photosensitization of DNA Damage by Glycated Proteins. Photochemistry and Photobiology Sciences 1, 355-363.

61. *Butts, B. D., Kwei, K. A., Bowden, G. T., and Briehl, M. M. (2003). Elevated basal reactive oxygen species and phospho-Akt in murine keratinocytes resistant to ultraviolent B-induced apoptosis. Mol. Carcinog. 37, 149-157.

62. Catania, J. M., Parrish, A. R., Kirkpatrick, D. S., Chitkara, M., Bowden, G. T., Henderson, C. J., Wolf, C. R., Clark, A. J., Brendel, K., Fisher, R. L., and Gandolfi, A. J. (2003). Precision-cut tissue slices from transgenic mice as an in vitro toxicology system. Toxicol In vitro 17, 201-205.

63. *Dilley, T., Bowden, G. T., and Chen, Q. M. (2003). Novel mechanisms of sublethal oxidant toxicity: induction of premature senescence in human fibroblasts confers tumor promoter activity. Exp. Cell. Res. 290, 38-48.

64. *Oshiro, M. M., Watts, G. S., Wozniak, R. J., Junk, D. J., Munoz-Rodriguez, J. L., Domann, F. E., and Futscher, B. W. (2003). Mutant p53 and aberrant cytosine methylation cooperate to silence gene expression. Oncogene 22, 3624-3634.

65. *Romagnolo, D. F., Chirnomas, R. B., Ku, J., Jeffy, B. D., Payne, C. M., Ramsey, L., Kunke, K., Bernstein, H., Holubec, H., Bhattacharyya, A. K., Warneke, J., and Garewal, H. (2003). Deoxyxholate, an endogenous tumor promoter and DNA damaging agent, modulates BRCA-1 expression in apoptosis-sensitive epithelial cells: loss of BRCA-1 expression in colonic adenocarcinomas. Nutr. Cancer 46, 82-92.

66. *Tu, V. C., Bahl, J. J., and Chen, Q. M. (2003). Distinct Role of ERKs and p38 MAPK in Oxidant-Induced AP-1 Activation and Cardiomyocyte Hypertrophy. Cardiovasc. Toxicol. 3, 119-133.

67. *Udayakumar, T. S., Chen, M. L., Bair, E. L., von Bredow, D. C., Cress, A. E., Nagle, R. B., and Bowden, G. T. (2003). Membrane type-1-matrix metalloproteinase expressed by prostate carcinoma cells cleaves human laminin-5 ?3 chain and induces cell migration. Cancer Res. 63, 2292-2299.

68. *Watts, G. S., Oshiro, M. M., Junk, D. J., Wozniak, R. J., Watterson, S., Domann, F. E., and Futscher, B. W. (2004). The acetyltransferase p300/CBP-associated factor (PCAF) is a p53 target gene in breast tumor cells. Neoplasia, In Press

Publications related to Center theme and/or productivity:

1. Alberts, D. S., Dorr, R. T., Einspahr, J., Aickin, M., Saboda, K., Xu, M. J., Peng, Y. M., Goldman, R., Foote, J. A., Warneke, J. A., Salasche, S., Roe, D. J., and Bowden, G. T (2000). Chemoprevention of human actinic keratoses by topical 2-(difluoromethyl)-dl-ornithine. Epidemiology, Biomarkers, & Prevention 9, 1281-1286.

2. Huang, C., Li, J., Chen, N., Ma, W., Bowden, G. T, and Dong, Z. (2000). Inhibition of atypical PKC blocks ultraviolet-induced AP-1 activation by specifically inhibiting ERKs activation. Mol. Carcinog. 27, 65-75.

3. Witkowski, C. M., Bowden, G. T, Nagle, R. B., and Cress, A. E. (2000). Altered surface expression and increased turnover of the ?6?4 integrin in an undifferentiated carcinoma. Carcinogenesis 21, 325-330.

4. Bair, E. L., Massey, C. P., Tran, N. L., Borchers, A. H., Heimark, R. L., Cress, A. E., and Bowden, G. T (2001). Integrin and cadherin mediated induction of the matrix metalloprotease matrilysin in co-cultures of malignant oral squamous cell carcinoma and dermal fibroblasts. Exp. Cell. Re.s 270, 259-267.

5. Davis, T. L., Rabinovitz, I., Futscher, B. W., Schnoelzer, M., Buerger, F., Liu, Y., Kulesz-Martin, M., and Cress, A. E. (2001). Identification of a Novel Structural Variant of the ?6 Integrin. J. Biol. Chem. 276, 26099-26106.

6. DeRoock, I. B., Pennington, M. E., Sroka, T. C., Lam, K. S., Bowden, G. T, Bair, E. L., and Cress, A. E. (2001). Synthetic peptides inhibit adhesion of human tumor cells to extracellular matrix proteins. Cancer Res. 61, 3308-3313.

7. Duan, W., Rangan, A., Vankayalapati, H., Kim, M.-Y., Zeng, Q., Sun, D., Han, H., Fedoroff, O. Y., Nishioka, D., Rha, S. Y., Izbicka, E., Von Hoff, D. D., and Hurley, L. H. (2001). Design and Synthesis of Fluoroquinophenoxazines that Interact with G-Quadruplexes and Their Biological Effects. Molecular Cancer Therapeutics 1, 103-120.

8. Efferth, T., Futscher, B. W., and Oseika, R. (2001). 5-azacytidine modulates the response of sensitive and multidrug resistant K52 leukemic cells to cytostatic drugs. Blood, Cells, Molecules and Diseases 27, 637-648.

9. Han, H., Rangan, A., Langley, D. R., and Hurley, L. H. (2001). Selective Interaction of Cationic Porphyrins with G-Quadruplex Structures. J. Am. Chem. Soc. 123, 8902-8913.

10. Hurley, L. H. and Zewail-Foote, M. (2001). The antitumor agent ecteinascidin 743: characterization of its covalent DNA adducts and chemical stability. Adv. Exp. Med. Biol. 500, 289-299.

11. Hurley, L. H. (2001). Secondary DNA structures as molecular targets for cancer therapeutics. Biochem. Soc. Trans. 29, 692-696.

12. Nomura, M., Kaji, A., Ma, W. Y., Zhong, S., Liu, G., Bowden, G. T, Miyamoto, K. I., and Dong, Z. (2001). Mitogen- and stress-activated protein kinase-1 (Msk1) mediates activation of Akt by ultraviolet B irradiation. J. Biol. Chem. 276, 25558-25567.

13. Rangan, A., Fedoroff, O. Y., and Hurley, L. H. (2001). Induction of Duplex to G-Quadruplex transition in the c-myc Promoter Region by a Small Molecule. J Biol Chem 276, 4640-4646.

14. Rutherford, T. J., Wilkie, J., Vu, C. Q., Schnackerz, K. D., Jacobson, M. K., and Gani, D. (2001). NMR studies and semi-empirical energy calculations for cyclic ADP- ribose. Nucleosides Nucleotides Nucleic Acids 20, 1485-1495.

15. Samuelson, D. J., Denise, S. K., Roffler, R., Ax, R. L., Armstrong, D. V., and Romagnolo, D. F. (2001). Response of Holstein and Brown Swiss cows fed alfalfa hay-based diets to supplemental methionine at two stages of lactation. J. Dairy Sci. 84, 917-928.

16. Samuelson, D. J., Powell, M. B., Lluria-Prevatt, M., and Romagnolo, D. F. (2001). Transcriptional activation of the gp91phox NADPH oxidase subunit by TPA in HL-60 cells. J. Leukoc. Biol 69, 161-168.

17. Shi, D. F., Wheelhouse, R. T., Sun, D., and Hurley, L. H. (2001). Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase. J. Med. Chem. 44, 4509-4523.

18. Stratton, M. S., Sirvent, H., Udayakumar, T. S., Nagle, R. B., and Bowden, G. T (2001). Expression of the matrix metalloproteinase promatrilysin in coculture of prostate carcinoma cell lines. Prostate 48 , 206-209.

19. Sun, D. and Hurley, L. H. (2001). Targeting telomeres and telomerase. Methods Enzymol .340, 573-592.

20. Tang, Q., Chen, W., Gonzales, M. S., Finch, J., Inoue, H., and Bowden, G. T (2001). Role of cyclic AMP responsive element in the UVB induction of cyclooxygenase-2 transcription in human keratinocytes. Oncogene 20, 5164-5172.

21. Tang, Q., Gonzales, M., Inoue, H., and Bowden, G. T (2001). Roles of Akt and glycogen synthase kinase 3? in the ultraviolet B induction of cyclooxygenase-2 transcription in human keratinocytes. Cancer Res. 61, 4329-4332.

22. Udayakumar, T. S., Klein, R. D., Maliner, M. S., Nagle, R. B., and Bowden, G. T (2001). Aberrant expression of fibroblast growth factor receptor-1 in prostate epithelial cells allows induction of promatrilysin expression by fibroblast growth factors. Int. J. Cancer 91, 187-192.

23. Zewail-Foote, M. and Hurley, L. H. (2001). Differential rates of Reversibility of Ecteinascidin 743-DNA Covalent Adducts from Different Sequences Lead to Migration to Preferred Bonding Sites. J. Am. Chem. Soc. 123, 6485-6495.

24. Bachelor, M. A., Silvers, A. L., and Bowden, G. T (2002). The role of p38 in UVA-induced cyclooxygenase-2 expression in the human keratinocyte cell line, HaCaT. Oncogene 21, 7092-7099.

25. Einspahr, J. G., Stratton, S. P., Bowden, G. T, and Alberts, D. S. (2002). Chemoprevention of human skin cancer. Crit. Rev. Oncol. Hematol. 41, 269-285.

26. Herzig, M. C. S., Rodriquez, K. A., Trevino, A. V., Dziegielewski, J., Arnett, B., Hurley, L. H., and Woynarowski, J. M. (2002). The Genome Factor in Region-specific DNA Damage: A DNA-reactive Drug U-78779 Prefers Mixed A/T-G/C Sequences at the Nucleotide Level But is Region-Specific For Long Pure AT Islands at the Genome Level. Biochemistry 41, 1545-1555.

27. Hurley, L. H. (2002). DNA and its associated processes as targets for cancer therapy. Nature Rev. Cancer 2, 188-200.

28. Jacobson, E.L. and Jacobson, M.K. (2002). Therapeutic Targeting of the PARPs: Future Challenges, Future Opportunities. In: Therapeutic Utilities of PARP Inhibitors (J. Zhang, Ed.), pp. 321-328. CRC Press LLC, Boca Raton, FL.

29. Kim, M. Y., Vankayalapati, H., Shin-Ya, K., Wierzba, K., and Hurley, L. H. (2002). Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex. J. Am. Chem. Soc. 124, 2098-2099.

30. Rezler, E. M., Bearss, D. J., and Hurley, L. H. (2002). Telomeres and telomerases as drug targets. Curr. Opin. Pharmacol. 2, 415-423.

31. Silvers, A. L. and Bowden, G. T (2002). UVA irradiation-induced activation of activator protein-1 is correlated with induced expression of AP-1 family members in the human keratinocyte cell line HaCaT. Photochem. Photobiol. 75, 302-310.

32. Stratton, M. S., Greenstein, B., Udayakumar, T. S., Nagle, R. B., and Bowden, G. T (2002). Androgens block interleukin-1 beta-induced promatrilysin expression in prostate carcinoma cells. Prostate 53, 1-8.

33. Udayakumar, T. S., Stratton, M. S., Nagle, R. B., and Bowden, G. T (2002). Fibroblast growth factor-1 induced promatrilysin expression through the activation of extracellular-regulated kinases and STAT3. Neoplasia. 4, 60-67.

34. Domann, F. E. and Futscher, B. W. (2003). Editorial: maspin as a molecular target for cancer therapy. J. Urol. 169, 1162-1164.

35. Duan, H., Zhang, H. J., Yang, J. Q., Overley, L. W., Futscher, B. W., and Domann, F. E. (2003). MnSOD Upregulates Maspin Tumor Suppressor Gene Expression in Human Breast and Prostate Cancer Cells. Antioxid. Redox. Signal. 5, 677-688.

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