Scientific Program

Wednesday Afternoon, January 4, 2006

Meeting Registration – Registration Area #2
General Session – Grand Ballroom

11:00 am Meeting Registration Begins

2:00 pm Introductions
Program Overview: Terrence J. Monks (University of Arizona)
Opening Remarks: Robert Snyder (Rutgers University)

2:30 pm Keynote Lecture: M.W. Anders (University of Rochester)
“Biological Reactive Intermediates: The Good, The Bad, and The Future”

3:30 pm Break – Grand Foyer

Session I: BRIs and New Reactive Intermediate Chemistry
Co-Chairs: Gary Yost (University of Utah) and Wolfgang Dekant (University of Wurzburg)

4:00 pm Paul Hollenberg (University of Michigan)
“Inactivation of Human P450a by Reactive Intermediates”

4:30 pm Lisa Peterson (University of Minnesota)
“Electrophilic Intermediates Produced By Bioactivation Of Furan”

5:00 pm Judy Bolton (University of Illinois)
“Bioactivation Of Selective Estrogen Receptor Modulators To Reactive Quinoids: Identification Of Protein Targets”

5:30 pm Christopher Reilly (University of Utah)
“Carbocations Involved In The Cytochrome P450-Mediated Dehydrogenation of Capsaicinoids”

6:00 pm Opening Reception – Waterfall (Weather Insurance: Arizona Deck and Foyer)

 

Thursday, January 5, 2006

Meeting Registration – Registration Area #2 General Session – Grand Ballroom
Poster Session – Arizona Foyer

Posters should be put up by 8:30 am

7:15 – 8:15 am Breakfast – Arizona Deck and Foyer

8:00 am Meeting Registration

Session II: BRIs and Drug Development
Co-Chairs: Tom Baillie (Merck) and Peter Moldeus (Astra Zeneca)

8:30 am George Doss (Merck)
“Addressing Metabolic Activation as an Integral Component of Drug Design”

9:00 am Eva Klasson Wehler (Astra Zeneca)
“Reactive Metabolite Formation - Addressing Risk In Drug Discovery”

9:30 am Sidney Nelson (University of Washington)
“ Structural Aspects Of Drug-Mediated Toxicities – Clinical Implications”

10:00 am Break and Poster Session 1 Viewing – Grand Foyer and Arizona Foyer

Session III: BRIs and Idiosyncratic Drug Reactions
Chair: Jack Uetrecht (University of Toronto)

10:30 am Kevin Park (University of Liverpool)
“Reactive Intermediates in Idiosyncratic Drug Reactions

11:00 am Thomas K.H. Chang (University of British Columbia) “Glucuronidation, Oxidative Stress, and Valproic Acid-induced Hepatotoxicity”

11:30 am Jack Uetrecht (University of Toronto) “Evaluation of Which Reactive Metabolite, if any, is Responsible for a Specific Idosyncratic Reaction”

12:00 pm Lunch and Poster Session 1 Viewing (Lunch is provided) – Arizona Deck and Foyer

Session IV: BRIs and DNA Damage and Repair
Co-Chairs: Trevor Penning (University of Pennsylvania) and Peter Dedon (MIT)

1:00 pm Peter Dedon (MIT)
“ DNA Damage and the Reactive Intermediates of Inflammation”

1:30 pm Ian Blair (University of Pennsylvania)
“ Cyclooxygenase and lipoxygenase-mediated formation of endogenous DNA-adducts”

2:00 pm Jean Cadet (Laboratoire "Lésions des Acides Nucléiques", DRFMC/SCIB CEA/Grenoble) “ Oxidation Reactions in Cellular DNA: Single and Clustered Damage”

2:30 pm Break and Poster Session 1 Viewing – Grand Foyer and Arizona Foyer

Session V: BRIs and Chromatin Structure And Function
Chair: Terrence J. Monks (University of Arizona)

3:00 pm Christopher C. Benz (Buck Institute for Age Research) “Novel Redox Cycling and Arylation Pathways Associated with Quinone Induced Stress in Breast Cancer Cells”

3:30 pm Terrence J. Monks (University of Arizona) “ROS-induced Histone Modifications and Their Role in Cell Survival and Cell Death”

4:00 pm Laurence Hurley (University of Arizona) “A Novel Oncogenic Silencing Mechanism Amenable to Small Molecule Targeting”

Selected Abstract Platform 1
Chair: David Williams (Oregon State University)

4:30pm Patrick M. Dansette (Universite Paris Descartes) “Cytochrome P450 Catalyzed Metabolism of Thiophenes: Glutathione Adducts from Both Thiophene-S-oxide and Thiophene Epoxide and Formation of Thiophene Hydrates”

4:45pm Jonathan Doorn (University of Iowa) “Inhibition of Mitochondrial Biotransformation of 3.4-Dihydroxyphenylacetaldehyde, a Reactive Intermediate of Dopamine Metabolism”

5:00pm David Ross (University of Colorado) “Generation of More Potent Anticancer Heat Shock Protein 90 (HSP90) Inhibitors by NQO1-mediated Metabolism of Benzoquinone Ansamycins”

5:15pm Axel Pähler (Hoffmann-La Roche Ltd.) “Reactive Metabolites in Drug Discovery and Early Development: In Vitro Approaches to Safe Drugs and Risk Assessment for Idiosyncratic Liver Toxicity”

5:30pm Poster Session 1 Viewing – Arizona Foyer

 

Friday, January 6, 2006

Meeting Registration – Registration Area #2 General Session – Grand Ballroom

Posters should be put up by 8:30 am

7:15 – 8:15 am Breakfast – Arizona Deck and Foyer

Session VI: Proteomics Approaches to BRI/Protein Interactions
Session 1: Chemistry of Protein Damage by BRI
Co-Chairs: Daniel Liebler (Vanderbilt University) and Serrine S. Lau (University of Arizona)

8:30 am Daniel Liebler (Vanderbilt University)
“Proteomic Approaches to Studying Protein Damage by BRI”

9:00 am Serrine S. Lau (University of Arizona)
“Identification of Protein Electrophile Binding Motifs for BRI”

9:30 am Harry Ischiropoulos (University of Pennsylvania)
“ Protein Modifications by Reactive Nitrogen Intermediates”

10:00 am Break - Grand Foyer

Session VII: Proteomics Approaches to BRI/Protein Interactions
Session 2: Protein Damage and Signaling by Endogenous Electrophiles
Co Chairs: Larry Marnett (Vanderbilt University) and Koji Uchida (Nagoya University)

10:30 am Lawrence Sayre (Case Western University)
“Protein Adducts Generated From Products Of Lipid Oxidation”

11:00 am Koji Uchida (Nagoya University)
“Endogenous Electrophiles And COX-2 Expression In Inflammation”

11:30 am Larry Marnett (Vanderbilt University)
“ Endogenous Electrophiles And Stress Signaling”

Selected Abstract Platform 2
Chair: Patrick M. Dansette (Universite Paris Descartes)

12:00 pm Amanda Bryant-Friedrich (Oakland University) “Oligonucleotide Fragmentation Products Derived from the C-3’-Thymidinyl Radical”

12:15 pm Richard N. Loeppky (University of Missouri) “Nitrolic Acids; New Reactive Intermediates and Their Adenine Adducts from the Nitrosation of Amino Acids”

12:30 pm Natalia Tretyakova (University of Minnesota) “Cross-linking of the Human DNA Repair Protein O6-Alkylguanine DNA Alkyltransferase to DNA in the Presence of 1,2,3,4-Diepoxybutane”

12:45 pm Vladimir Shafirovich (New York University) “Oxidative Damage in DNA Caused by Photoexcitation of a Site-specific Sensitizer: From Radical Injection to Chemical Product Formation Detected Via Alkali-labile Lesions”

1:00 pm Afternoon Free (Lunch on your own)

 

Saturday, January 7, 2006

Meeting Registration – Registration Area #2 General Session – Grand Ballroom
Poster Session – Arizona Foyer

Posters should be put up by 8:30 am

7:15 – 8:15 am Breakfast – Arizona Deck and Foyer

8:00 am Meeting Registration

Session VIII: BRIs and Modulation of Cell Signaling Pathways
Session 1: Transcriptional Responses to BRIs
Chair: John DiGiovanni (University of Texas, MD Anderson Cancer Center)

8:30 am John DiGiovanni (University of Texas, MD Anderson Cancer Center) “Stat3 Signaling and Cellular Response to Carcinogens and Tumor Promoters”

9:00 am Ze’ev Ronai (The Burnham Institute) “Transcription Factors in DNA Damage Response ATF2 in the Cross Roads of JNK/ATM Signaling”

9:30 am Donna Zhang (University of Arizona)
“ The Nrf2/Keap1 Signaling Pathway, Oxidative Stress, and Chemoprevention”

10:00 am Break and Poster Viewing – Grand Foyer and Arizona Foyer

Session IX: BRIs and Modulation of Cell Signaling Pathways
Session 2: Stress/Redox Response Signaling
Chair: Garth Powis (University of Texas, MD Anderson Cancer Center)

10:30 am Arne Holmgren (Medical Nobel Institute for Biochemistry) “Redox Signaling by Thioredoxin and Glutaredoxin Systems”

11:00 am Junji Yodoi (Kyoto University) “Redox Regulation of Lipid Raft by TRX and RBP-2 System”

11:30 am R. Clark Lantz (University of Arizona) “Role of Oxidative Stress in Arsenic-Induced Toxicity”

12:00 pm Lunch and Poster Session 2 Viewing (Lunch is provided) – Arizona Deck and Foyer

Session IX: Global Responses to BRIs
Chair: Ken Ramos (University of Louisville)

1:00 pm Teresa Fan (University of California, Davis/University of Louisville) “Integrating Genomics and Metabolomics”

1:30 pm Ken Ramos (University of Louisville) “Modulation of Biological Regulatory Networks During Nephrogenesis”

2:00 pm Ilya Shmulevich (Institute for Systems Biology) “Probabilistic Boolean Networks”

2:30 pm Break and Poster Session 2 Viewing – Grand Foyer and Arizona Foyer

4:00 pm Closing Remarks and Future Directions: Jack H. Dean (Sanofi - Aventis)

6:00 pm Closing Reception – Arizona Deck and Foyer