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Primary Phone: (520) 6267470
Skaggs College of Pharmacy
1703 E Mabel
Tucson AZ 85721
Primary Phone: (520) 6267470
Ph.D., Pharmacology and Toxicology, University of Arizona, 1994
D.V.M., Ohio State University, 1984
- College Of Medicine
- College Of Public Health
- College Of Pharmacy
Associating human genetic backgrounds and diverse environmental exposures to understand individual variability in disease susceptibility. Metals Toxicology, Mechanism of Action of Arsenic, Toxicity Toxicant Disruption of Cellular Metabolism
Environmental Health Research & Expertise:
Dr. Klimecki’s research spans the translational spectrum, from the use of basic experimental models of toxicology in mechanism of action studies to epidemiological studies of toxicant exposed human populations. Dr. Klimecki’s work in human studies of arsenic-exposed populations has defined important predictors of “safer” and “less safe” arsenic bioconversion, including gender, body mass index, genetic variation in the AS3MT gene, and the degree of indigenous American ancestry. His “bench” mechanistic toxicology studies have identified novel consequences of arsenic exposure. Klimecki’s group was among the first to characterize autophagy, a process of cellular organelle self-catabolism , as a key process resulting from arsenite exposure to cultured cells. More recently, his group has broken new ground in our understanding of the ability of arsenic to perturb fundamental energy metabolism in human cells. His group demonstrated that cells, even cells that are exposed to abundant oxygen, launch an arsenic response that is more typically associated with hypoxic stress. Part of this response is switching energy metabolism from oxidative phosphorylation to glycolysis. This energy metabolism re-programming has important consequences on the resulting cellular phenotype and may underlie arsenic-induced human pathology.
- Arsenite-induced autophagy is associated with proteotoxicity in human lymphoblastoid cells.
- Metals in residential soils and cumulative risk assessment in Yaqui and Mayo agricultural valleys, northern Mexico.
- Altered arsenic disposition in experimental nonalcoholic Fatty liver disease.
- Autophagy in toxicology: self-consumption in times of stress and plenty.
- A SOCS-1 promoter variant is associated with total serum IgE levels.
- Analysis of global and absorption, distribution, metabolism, and elimination gene expression in the progressive stages of human nonalcoholic fatty liver disease.
- Association between body mass index and arsenic methylation efficiency in adult women from southwest U.S. and northwest Mexico.
- Arsenite exposure in human lymphoblastoid cell lines induces autophagy and coordinated induction of lysosomal genes.
- Autophagy is the predominant process induced by arsenite in human lymphoblastoid cell lines.
- How can biologically-based modeling of arsenic kinetics and dynamics inform the risk assessment process? - A workshop review.
- Developmental and genetic modulation of arsenic biotransformation: a gene by environment interaction?
- Epigenetic inactivation of the HOXA gene cluster in breast cancer.
- Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes. Previous years
- Indigenous American ancestry is associated with arsenic methylation efficiency in an admixed population of northwest Mexico.
- Guidelines for the use and interpretation of assays for monitoring autophagy.
- Genetic association between intronic variants in AS3MT and arsenic methylation efficiency is focused on a large linkage disequilibrium cluster in chromosome 10.
- Th2 cell-selective enhancement of human IL13 transcription by IL13-1112C>T, a polymorphism associated with allergic inflammation.
- Automated high-throughput sex-typing assay.
- Performance assessment of eight high-throughput PCR assays for viral load quantitation of oncogenic HPV types.
- Genetic variation in genes associated with arsenic metabolism: glutathione S-transferase omega 1-1 and purine nucleoside phosphorylase polymorphisms in European and indigenous Americans.
- Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studies.
- Longitudinal decline in lung function: evaluation of interleukin-10 genetic polymorphisms in firefighters.
- Association of defensin beta-1 gene polymorphisms with asthma.
- Epigenetic regulation of the cell type-specific gene 14-3-3sigma.
- Association of atopy and eczema with polymorphisms in T-cell immunoglobulin domain and mucin domain-IL-2-inducible T-cell kinase gene cluster in chromosome 5 q 33.
- Cross-sectional analysis of oncogenic HPV viral load and cervical intraepithelial neoplasia.
- Developmentally restricted genetic determinants of human arsenic metabolism: association between urinary methylated arsenic and CYT19 polymorphisms in children.
- Single-nucleotide polymorphisms in the interleukin-10 gene: differences in frequencies, linkage disequilibrium patterns, and haplotypes in three United States ethnic groups.