Stump, Craig

Office Location:

1656 E. Mabel Street

Primary Phone: (520) 6263709

PhD, University of Arizona, 1986

MD, University of Arizona, 1997

College Affiliations:
  • College Of Medicine
Research Interests:

diabetes, hypertension, metabolic syndrome, insulin resistance resulting from physical inactivity, obesity and the metabolic syndrome; renin-angiotensin system (RAS), reactive oxygen species (ROS), and inflammation in skeletal muscle insulin signaling;  insulin resistance and RAS on mitochondrial energy (ATP) production; identifying biological markers to predict progression of diabetes

Environmental Health Research & Expertise:

My laboratory investigates mechanisms contributing to insulin resistance that occur as a result of physical inactivity, obesity, and the cardiometabolic syndrome. We are particularly interested in defining the contribution of the renin-angiotensin-aldosterone system (RAAS), reactive oxygen species (ROS) and inflammation in preventing normal skeletal muscle insulin signaling. Skeletal muscle cell and tissue cultures, and whole animal responses to insulin by euglycemic-hyperinsulinemic clamp are used to study cellular insulin signaling pathways and tissue responses to insulin. I am also studying the effects of insulin resistance on mitochondrial energy (ATP) production in skeletal muscle and exercise capacity.