Clark Lantz

Center Deputy Director
Facility Co-Leader
Cellular Imaging Facility Core Director
Research Focus Group Membership: 
Research Focus Group 2
Education: 

Ph.D., West Virginia University 1975
B.S., Juniata College 1970

College Affiliations: 

College Of Medicine
College Of Public Health

Research Interests: 

Pulmonary Toxicology, Biological Imaging, Pathogenesis, Developmental Biology

Environmental Health Research & Expertise: 

Dr. R. Clark Lantz is Professor of Molecular and Cellular Medicine, and Professor, Division of Community, Environment and Policy at the University of Arizona.   Dr. has been the Deputy Director of the Southwest Environmental Health Science Center since 2000. He is intimately familiar with all aspects of the SWEHSC, having been involved with the Center since its inception. As the Deputy Director, he works closely with the Director, Dr. Lau. In the Director's absence, Dr. Lantz has represented the SWEHSC at Center Directors meetings. He is a member of the Center management team that meets weekly. He currently is Chair of the COEC Stakeholders Committee. He has served as the Director of Cellular Imaging Facility since the SWEHSC was first funded in 1993. He is also serving as the leader of the current Research Focus Group 2, Environmental Lung Diseases, where he has been successful in expanding the size and the research interactions of the group. Dr. Lantz also serves as the Deputy Director of the Arizona Superfund Research Program and is Principal Investigator of a Superfund Research Project.  Dr. Lantz is heavily involved with issues related to bioinstrumentation at the University. He is the Chair of the University-wide Imaging Facilities User Committee that provides input to the Director of Biotechnology on policy and procedures related to the University imaging facilities and also evaluates University needs in imaging instrumentation and prioritizes those needs. Dr. Lantz maintains active research projects that examine the pulmonary toxicity of arsenic and uranium, especially during lung development.  His most recent research has focused on the effects of water ingestion or inhalation of arsenic and other dusts on lung growth and development and on identification of arsenic and uranium induced pulmonary biomarkers. Dr. Lantz has identified several phenotypic alterations caused by the exposure to environmentally relevant levels of arsenic.  A number of these phenotypic alterations have been validated in human population studies studied in Arizona and Mexico.  His research has been funded from the National Institutes of Health (NIEHS, NCI) and from the USEPA.  Dr. Lantz is the author of over 85 peer reviewed manuscripts.  Dr. Lantz received the Career Achievement Award, Inhalation and Respiratory Specialty Section, Society of Toxicology in 2011 in recognition of his work in inhalation and respiratory toxicology.

Select Publications

2015

Recio-Vega, R., T. Gonzalez-Cortes, E. Olivas-Calderon, C. R Lantz, J. A Gandolfi, and C. Gonzalez- De Alba, "In utero and early childhood exposure to arsenic decreases lung function in children.", J Appl Toxicol, vol. 35, issue 4, pp. 358-66, 2015 Apr. PubMed PMCID: PMC4750377  PMID: 25131850

2014

Burgess, J. L., M. Kurzius-Spencer, G. S. Poplin, S. R. Littau, M. J. Kopplin, S. Stürup, S. Boitano, and C. R Lantz, "Environmental arsenic exposure, selenium and sputum alpha-1 antitrypsin.", J Expo Sci Environ Epidemiol, vol. 24, issue 2, pp. 150-5, 2014 Mar-Apr. PubMed PMCID: PMC4019207  PMID: 23838883

2013

Tao, S., Y. Zheng, A. Lau, M. C. Jaramillo, B. T. Chau, C. R Lantz, P. K. Wong, G. T. Wondrak, and D. D. Zhang, "Tanshinone I activates the Nrf2-dependent antioxidant response and protects against As(III)-induced lung inflammation in vitro and in vivo.", Antioxid Redox Signal, vol. 19, issue 14, pp. 1647-61, 2013 Nov 10. PubMed PMCID: PMC3809600  PMID: 23394605
Sherwood, C. L., C. R Lantz, and S. Boitano, "Chronic arsenic exposure in nanomolar concentrations compromises wound response and intercellular signaling in airway epithelial cells.", Toxicol Sci, vol. 132, issue 1, pp. 222-34, 2013 Mar. PubMed PMCID: PMC3576008  PMID: 23204110
Sherwood, C. L., A. E. Liguori, C. E. Olsen, C. R Lantz, J. L. Burgess, and S. Boitano, "Arsenic compromises conducting airway epithelial barrier properties in primary mouse and immortalized human cell cultures.", PLoS One, vol. 8, issue 12, pp. e82970, 2013. PubMed PMCID: PMC3857810  PMID: 24349408