Julie Ledford

Research Focus Group Membership: 
Research Focus Group 2
  • BS, Genetics, University of Georgia, 2000
  • PhD, Genetics and Molecular Biology, University of North Carolina, 2006
College Affiliations: 

College of Pharmacy
College of Medicine

Research Interests: 

Respiratory disease, genetic and molecular mechanisms of allergic airway diseases in children

Environmental Health Research & Expertise: 

Dr. Ledford’s current work in the area of pulmonary surfactant immunobiology combines her knowledge of mouse genetics, pulmonary disease models and immune function regulation and focuses on understanding the role of Surfactant Protein-A (SP-A) and how it regulates signaling pathways within various immune cell populations. Specifically, she is interested in how SP-A regulates degranulation, either directly or indirectly, of two important cell types in asthma: mast cells and eosinophils. More recently, Dr. Ledford’s research has focused on understanding how genetic variation within human SP-A2 alters functionality of the protein in relation to eosinophil activities and how this translates to characteristics observed in human asthma.