Scott Boitano

Member
Research Focus Group Membership: 
Research Focus Group 2
Education: 

Ph.D., Washington State 1991

College Affiliations: 

College of Medicine

Research Interests: 

Cell Biology, Microbiology, Molecular Biology, Pathogenesis, Physiological Sciences, Toxicology

Environmental Health Research & Expertise: 

The goal of the center is to provide a collaborative environment with cutting edge cores to foster novel research on environmental exposures. Within the center, Dr. Boitano works closely with all of the pulmonary core members and provide a unique cell biology perspective. This perspective comes from over 20 years experience in lung cell biology. Dr. Boitano's research in airway epithelial cells started with second messenger signaling and communication in unique primary cellular models from the conducting and the alveolar airway. His focus has shifted to evaluating airway signaling and junctional structure/function in response to environmental changes. Such changes have included pathogens (e.g. Bordetella sp. and Alternaria alternata), and environmental toxicants (e.g., arsenic). With respect to arsenic, his lab has successfully integrated cellular work with other center investigators including animal models from Dr. R. Clark Lantz' laboratory and human populations from Dr. Jefferey Burgess' laboratory. Within the framework of the Southwest Environmental Health Sciences Center, he will continue to provide cellular mechanistic studies that can complement work from established collaborations as well as work from others in the center.

Select Publications

2014

Burgess, J. L., M. Kurzius-Spencer, G. S. Poplin, S. R. Littau, M. J. Kopplin, S. Stürup, S. Boitano, and C. R Lantz, "Environmental arsenic exposure, selenium and sputum alpha-1 antitrypsin.", J Expo Sci Environ Epidemiol, vol. 24, issue 2, pp. 150-5, 2014 Mar-Apr. PubMed PMCID: PMC4019207  PMID: 23838883
Sherwood, C. L., M. O. Daines, T. J. Price, J. Vagner, and S. Boitano, "A highly potent agonist to protease-activated receptor-2 reveals apical activation of the airway epithelium resulting in Ca2+-regulated ion conductance.", Am J Physiol Cell Physiol, vol. 307, issue 8, pp. C718-26, 2014 Oct 15. PubMed PMCID: PMC4199996  PMID: 25143347
Boitano, S., J. Hoffman, D. V. Tillu, M. N. Asiedu, Z. Zhang, C. L. Sherwood, Y. Wang, X. Dong, T. J. Price, and J. Vagner, "Development and evaluation of small peptidomimetic ligands to protease-activated receptor-2 (PAR2) through the use of lipid tethering.", PLoS One, vol. 9, issue 6, pp. e99140, 2014. PubMed PMCID: PMC4057235  PMID: 24927179

2013

Sherwood, C. L., C. R Lantz, and S. Boitano, "Chronic arsenic exposure in nanomolar concentrations compromises wound response and intercellular signaling in airway epithelial cells.", Toxicol Sci, vol. 132, issue 1, pp. 222-34, 2013 Mar. PubMed PMCID: PMC3576008  PMID: 23204110
Sherwood, C. L., A. E. Liguori, C. E. Olsen, C. R Lantz, J. L. Burgess, and S. Boitano, "Arsenic compromises conducting airway epithelial barrier properties in primary mouse and immortalized human cell cultures.", PLoS One, vol. 8, issue 12, pp. e82970, 2013. PubMed PMCID: PMC3857810  PMID: 24349408