Yin Chen

Member
Research Focus Group Membership: 
Research Focus Group 2
Education: 

PhD, Genetics, 2001, University of California, Davis

College Affiliations: 

College of Pharmacy

Research Interests: 

Airway epithelial signaling transduction, transcriptional regulation, function of epithelial mucin genes, innate defense against viral and fungal infections. Molecular pathogenesis of asthma, asthma exacerbation, and COPD. 

Environmental Health Research & Expertise: 

Dr. Yin Chen is a member of RFG2. His research interest is to understand the dysfunction of airway epithelium in the pathogenesis of a variety of acute and chronic airway disease including asthma and COPD. His focus is the translational research that connects the basic mechanism and the clinical observation. Dr. Chen has established a productive track record in the field of airway epithelial innate defense with more than 30 publications. Since his arrival at Arizona, Dr. Chen has established several joint projects with other SWEHSC investigators and has brought in more than 2 million federal and state grant funding.

Select Publications

2014

Oslund, K. L., X. Zhou, B. Lee, L. Zhu, T. Duong, R. Shih, N. Baumgarth, L-Y. Hung, R. Wu, and Y. Chen, "Synergistic up-regulation of CXCL10 by virus and IFN γ in human airway epithelial cells.", PLoS One, vol. 9, issue 7, pp. e100978, 2014. PubMed PMCID: PMC4102466  PMID: 25033426

2013

Zhu, L., E. C. Barrett, E. C. Barret, Y. Xu, Z. Liu, A. Manoharan, and Y. Chen, "Regulation of Cigarette Smoke (CS)-Induced Autophagy by Nrf2.", PLoS One, vol. 8, issue 4, pp. e55695, 2013. PubMed PMCID: PMC3621864  PMID: 23585825

2011

Fujisawa, T., M. Mann- Jong Chang, S. Velichko, P. Thai, L-Y. Hung, F. Huang, N. Phuong, Y. Chen, and R. Wu, "NF-κB mediates IL-1β- and IL-17A-induced MUC5B expression in airway epithelial cells.", Am J Respir Cell Mol Biol, vol. 45, issue 2, pp. 246-52, 2011 Aug. PubMed PMCID: PMC3175554  PMID: 20935193