Zelieann Craig

Member
Research Focus Group Membership: 
Research Focus Group 3
Education: 

Ph.D., University of Arizona, 2009, Physiological Sciences
University of Puerto Rico, 2004, Industrial Microbiology

College Affiliations: 

College of Agriculture and LIfe Sciences

Research Interests: 

Female Reproductive Toxicology

Environmental Health Research & Expertise: 

Infertility is the inability to produce life offspring. Several factors increase a female’s risk for infertility including aging, stress, and exposure to chemicals. Unfortunately, fertility in women and animals has declined significantly over several decades. Therefore, understanding how these factors influence human and animal fertility are of great health and economic importance. A group of chemicals collectively known as phthalates have been classified as endocrine disruptors based on their ability to interact with the reproductive system. Phthalates have been detected in human urine, animal tissues, and feed. Despite these observations, knowledge about how phthalates interact with the female reproductive system is currently very limited. Dr. Craig's work focuses on understanding how phthalates affect the function of the ovary, the major reproductive organ in females. Thus, work in her laboratory is focused on using animal models to help us understand the mechanisms by which phthalates exert their effects on the ovary, determine whether phthalates cause female infertility, and examine whether the effects of phthalates on female reproduction can be prevented or reversed. Using this knowledge she hopes to develop additional models to evaluate other chemicals and environmental factors that could influence both human and animal reproduction.

Select Publications

2015

Sen, N., X. Liu, and Z. R. Craig, "Short term exposure to di-n-butyl phthalate (DBP) disrupts ovarian function in young CD-1 mice.", Reprod Toxicol, vol. 53, pp. 15-22, 2015 Jun. PubMed PMCID: PMC4457581  PMID: 25765776

2014

Craig, Z. R., J. Singh, R. K. Gupta, and J. A. Flaws, "Co-treatment of mouse antral follicles with 17β-estradiol interferes with mono-2-ethylhexyl phthalate (MEHP)-induced atresia and altered apoptosis gene expression.", Reprod Toxicol, vol. 45, pp. 45-51, 2014 Jun. PubMed PMCID: PMC4028413  PMID: 24412242

2013

Ziv-Gal, A., Z. R. Craig, W. Wang, and J. A. Flaws, "Bisphenol A inhibits cultured mouse ovarian follicle growth partially via the aryl hydrocarbon receptor signaling pathway.", Reprod Toxicol, vol. 42, pp. 58-67, 2013 Dec. PubMed PMCID: PMC3836856  PMID: 23928317
Craig, Z. R., P. R. Hannon, and J. A. Flaws, "Pregnenolone co-treatment partially restores steroidogenesis, but does not prevent growth inhibition and increased atresia in mouse ovarian antral follicles treated with mono-hydroxy methoxychlor.", Toxicol Appl Pharmacol, vol. 272, issue 3, pp. 780-6, 2013 Nov 1. PubMed PMCID: PMC3805676  PMID: 23948739
Craig, Z. R., P. R. Hannon, W. Wang, A. Ziv-Gal, and J. A. Flaws, "Di-n-butyl phthalate disrupts the expression of genes involved in cell cycle and apoptotic pathways in mouse ovarian antral follicles.", Biol Reprod, vol. 88, issue 1, pp. 23, 2013 Jan. PubMed PMCID: PMC4434941  PMID: 23242528