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Lau Laboratory
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Jessica Sapiro
Education:
- Graduate Student Pharmacology and Toxicology University of Arizona 2010-Present
- M.S. Nutritional Sciences University of Minnesota-Twin Cities 2008
- B.S. Nutritional Sciences University of Wisconsin-Madison 2006
Achievements:
- University of Minnesota Thank a Teacher Award 2007
Professional Experience:
- Toxicology Researcher, Alnylam Pharmaceuticals 2008-2010
Mentee:
Yurika Isoe |
Research Project:
Jessica’s research focuses on the mechanisms by which Grp78 and the endoplasmic reticulum stress response stimulate cytoprotection in acute kidney injury. My experimental design will involve both in vivo and in vitro studies. Models for ischemia reperfusion injury as well as chemical-induced renal injury will be developed. To elucidate the specific role of Grp78 and the endoplasmic reticulum stress response in cytoprotection, cells will be stably transfected with antisense Grp78 RNA and mRNA, protein, and cell viability levels will be determined.
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Publications:
- Sapiro, J.M., Mashek, M.T., Greenberg, A.S., and Mashek, D.G. Hepatic Triacylglycerol Hydrolysis Regulates Peroxisome Proliferator-Activated Receptor α Activity. J. Lipid Res. 50:1621-1629, 2009.
Abstracts:
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Sapiro, J.M. 2010. Safety Assessment and Concerns Around 2’Fluoro-Substituted Oligonucleotide Drugs. Boston Area Pharmacology and Toxicology Interest Group Conference, April 1, 2010.
- Sapiro, J.M., Mashek, M.T., and Mashek, D.G. Fatty Acids Derived from Triacylglycerol Hydrolysis are a Significant Source of Ligands for Peroxisome Proliferator-Activated Receptor-Alpha (PPAR-α) in Rat Primary Hepatocytes. FASEB J. 22:807.19, 2009.
- Sapiro, J.M. and Sunde, R.A. The Effect of Dietary Selenium and Genotype on Growth and Selenoenzyme Activity in Wild Type and Glutathione Peroxidase-1 Knockout Mice. University of Wisconsin-Madison College of Agricultural and Life Sciences Research Symposium, April 29, 2006.
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Past and present staff
Present
Graduate Students
Ryan Canatsey | Owen Kinsky | Chris Kuhlman | Nick Mastrandrea | Jessica Sapiro | Kevin Xu
Present Postdoctoral Fellow
Tim Radabaugh
Research Associate
Alfred Gallegos
Clinical Faculty Mentee
Hussein Yassine
Current Undergraduate Students
Wesley Cai, Itzel Rojas, Audrey Shi, Kim Tham
Recent Past Staff
Martina Bowen | Jennifer Cohen | Ashley
Fisher | Chris Hattan | Mike Kimzey | Matt Labenski | Jean Lord-Garcia
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