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Lau Laboratory
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Owen Kinsky
Education:
- Graduate Student Pharmacology and Toxicology University of Arizona 2009-Present
- B.A. Chemistry University of Minnesota, Morris 2009
Achievements:
- ASPET Graduate Student Travel Award 2012
- Caldwell Health Sciences Award 2012
- SOT Graduate Student Travel Award 2011
- NIEHS Toxicology and Toxicogenomics Training Program Predoctoral Trainee 2011-present
- Scholar of the College, University of Minnesota, Morris 2009
- Dean's Scholarship, University of Minnesota, Morris 2006-2009
- UROP Grant, University of Minnesota, Morris 2008
Professional Experience:
- Laboratory technician, 3M Dyneon LLC 2008
- Undergraduate Researcher, UROP Grant, University of Minnesota Morris 2008
- Undergraduate Researcher, IREE Grant, University of Minnesota, Morris 2007
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Research Project:
Owen’s graduate research project is to investigate the relationship between glycooxidation and the thrombolytic cascade in diabetes. Using advanced techniques such as mass spectrometry based multiple reaction monitoring technology, glycooxidative adducts are being identified from our cohort of 151 samples, which are collected from normal and pre-diabetic and diabetic patients. Using global mass spectrometric proteomics approach we found that, methylglyoxal (a byproduct of glycolysis which is elevated in diabetes) modified plasminogen has been found at an arginine residue important to the cleavage of plasminogen. Without this cleavage, the entire thrombolytic cascade can be halted. This methylglyoxal adducted arginine on plasminogen may be adding to the deleterious cardiovascular complications at are seen in diabetes. |
Publications:
Abstracts:
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Identification of Hydroimidazolone And Argpyrimidine Adducts as Glycooxidative Biomarkers in Type 2 Diabetic Subjects. Kinsky, O.R., Kimzey, M.J., Yassine, H.N., Stump, C.S., Tsaprailis, G., Monks, T.J. and Lau, S.S. Toxicologist, 105, 913, 2011.
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High Lipid Content Microalgae for Biofuels: Species Evaluation. Kinsky, O.R., Korth, R.A., Carpenter, N.E., Ruan, R.R., Kong, Q., Martinez, B., and Chen, P. E3 Conference. Minneapolis, MN, 2007.
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Past and present staff
Present
Graduate Students
Ryan Canatsey | Owen Kinsky | Chris Kuhlman | Nick Mastrandrea | Jessica Sapiro | Kevin Xu
Present Postdoctoral Fellow
Tim Radabaugh
Research Associate
Alfred Gallegos
Clinical Faculty Mentee
Hussein Yassine
Current Undergraduate Students
Wesley Cai, Itzel Rojas, Audrey Shi, Kim Tham
Recent Past Staff
Martina Bowen | Jennifer Cohen | Ashley
Fisher | Chris Hattan | Mike Kimzey | Matt Labenski | Jean Lord-Garcia
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