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Lau Laboratory
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Hussein Yassine
Education:
- Residency Case Western Reserve University, Cleveland, Ohio 2007-2004
- Internship American University of Beirut, Beirut , Lebanon 2004-2003
- M.D. Beirut Arab University, Beirut, Lebanon 2003
Achievements:
Professional Experience:
- Assistant Professor, College of Medicine, University of Arizona, 2010-present
- Clinical Collaborator to the Lau Laboratory, 2008-present
- Research Fellow, University of Arizona, Tucson, AZ 2008-2010
- Research Scholar Schwartz Center of Metabolism, Cleveland, Ohio 2005-2006
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Research Project:
I am an Assistant Professor in the department of Medicine. I am a diplomat of the American Boards of Clinical Lipidology and Endocrinology, and I direct the Lipid Clinic at University of Arizona. The research goal of my laboratory is to investigate the High Density Lipoprotein (HDL) proteome in cardiovascular disease. Specifically, we are defining HDL protein phenotypes in setting of low HDL cholesterol, diabetes and cardiovascular disease, and relating changes of HDL proteins to its function. We are also interested in the effect of fat challenge and lipid therapies on the HDL proteome. In a collaborative effort with the Molecular Biosignatures Analysis Unit at Arizona State University (Led by Dr. Randall Nelson), we obtained NIH funding to design a clinical cohort of subjects with and without diabetes and cardiovascular disease for discovering diabetes biomarkers. With a strong collaboration and mentorship from the Dr. Serrine Lau, I am developing a translational program to apply advanced mass spectrometry technologies for the discovery of diabetes and cardiovascular disease biomarkers. |
Publications:
- Kimzey, M.J., Yassine, H.N., Riepel, B.M., Tsaprailis, G., Monks, T.J. and Lau, S.S. New Site(s) of Methylglyoxal-modified human serum albumin, identified by multiple reaction monitoring, alter warfarin binding and prostaglandin metabolism. Chemico-Biol Int. 192: 122-128, 2011.
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Yassine, H.N., Davis-Gorman, G., Stump, C.S., Thomson, S.S., Peterson, J., and McDonagh, P.F. Effect of glucose or fat challenge on aspirin resistance in diabetes. Int J Endocrinol 2010, 820876.
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Yassine HN, Gorman-Davis, Stump CS, Thomson ST, Peterson J, McDonagh FP. Clinical Determinants of Aspirin Resistance in Diabetes. Diabetes Research and Clinical Practice. (90): e19-e21, 2010.
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Yassine H N, Stump C.S. Cardiometabolic Syndrome, Diabetes and Oxidative Stress: Focus on the Aging Population. Handbook of Nutrition in the Aged, Fourth Edition. Taylor & Francis. Watson RR, Chapter 7, 2008
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Yassine H.N., Marchetti C.M., Krishnan R.K., Vrobel T.R., Gonzalez F., Kirwan J.P. Effects of Exercise and Caloric Restriction on Insulin Resistance and Cardiometabolic Risk Factors in Older Obese Adults — A Randomized Clinical Trial. J Gerontol A Biol Sci Med Sci. 2009 Jan.
Abstracts:
- Identification of Hydroimidazolone And Argpyrimidine Adducts as Glycooxidative Biomarkers in Type 2 Diabetic Subjects. Kinsky, O.R., Kimzey, M.J., Yassine, H.N., Stump, C.S., Tsaprailis, G., Monks, T.J. and Lau, S.S. Toxicologist, 105, 913, 2011.
- Quantitation of Proteomic Markers of Glyco-Oxidation Using Multiple Reaction Monitoring. Kimzey, M.J., Yassine, H.N., Stump, C.S., Tsaprailis, G., Monks, T.J. and Lau, S.S. VIII International Symposium on Biological Reactive Intermediates Abstract Proceeding, Barcelona, Spain July 15-18, 2010.
- Quantitative Analysis of Oxidative Modifications in HDL using MRM. Yassine, H.N., Kimzey, M.J., Galligan, M.A., Stump, C.S., Tsaprailis, G. and Lau, S.S. J. Am. Soc. Mass. Spec., ThP06, 141, 2010.
- Effect of Glyco-oxidative Modifications on Plasma Fibrinogen Function in Diabetes. Yassine, H.N., Kimzey, M.J., Galligan, M.A., Stump, C.S., Tsaprailis, G. and Lau, S.S. J. Am. Soc. Mass. Spec., ThP06, 162, 2010.
- Quantitation of Proteomic Markers of Glyco-Oxidation Using Multiple Reaction Monitoring. Kimzey, M.J., Yassine, H.N., Galligan, M., Stump, C.S., Tsaprailis, G. and Lau, S.S. J. Am. Soc. Mass. Spec., TP07, 188, 2010.
- Identification of candidate plasma biomarkers for diabetic complications: In vivo methylglyoxal modified hotspots. Kimzey, M., Galligan, M.A., Yassine, H., Stump, C., Tsaprailis, G. and Lau, S.S. J. Am. Soc. Mass. Spec., ThPV565, 20(5S), S143, 2009.
- Plasma methylglyoxal and correlation with the severity of diabetic albuminuria. Yassine, H., Kimzey, M., Alvarez, I., Stratton, S. Stump, S., Tsaprailis, G., Galligan, M.A. and Lau, S.S. J. Am. Soc. Mass. Spec., TPZ624, 20(5S), S84, 2009.
- Identification of candidate plasma biomarkers for type-2 diabetes: in vivo methylglyoxal modified hotspots. Kimzey, M., Galligan, M.A., Yassine, H., Stump, C., Tsaprailis, G. and Lau, S.S. Late Breaking Abstracts, 2009 Annual Meeting of the Society of Toxicology, Baltimore, MD.
- Proteomic analysis of rat and human plasma in search of potential biomarkers for Type 2 Diabetes. Galligan, M., Kimzey, M., Radabaugh, T.R., Tsaprailis, G., Link, D.C., Borges, C.R., Yassine, H., Henriksen, E.J., Nelson, R., Stump, C.S., and Lau, S.S. J. Am. Soc. Mass. Spec., Poster number MP526, 19(5S), S50, 2008.
- Identification of methyglyoxal modified proteins in diabetic plasma using MudPIT. Kimzey, M., Galligan, M., Radabaugh, T.R., Borges, C.R., Yassine, H., Nelson, R., Link, D.C., Henriksen, E.J., Stump, C.S., Tsaprailis, G., Lau, S.S. J. Am. Soc. Mass. Spec., Poster number TP463, 19(5S), S76, 2008.
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Past and present staff
Present
Graduate Students
Ryan Canatsey | Owen Kinsky | Chris Kuhlman | Nick Mastrandrea | Jessica Sapiro | Kevin Xu
Present Postdoctoral Fellow
Tim Radabaugh
Research Associate
Alfred Gallegos
Clinical Faculty Mentee
Hussein Yassine
Current Undergraduate Students
Wesley Cai, Itzel Rojas, Audrey Shi, Kim Tham
Recent Past Staff
Martina Bowen | Jennifer Cohen | Ashley
Fisher | Chris Hattan | Mike Kimzey | Matt Labenski | Jean Lord-Garcia
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