Serrine S. Lau

Education:

• August 1974, B.S., University of Houston (Major: Mathematics and Chemistry)
• December 1980, Ph.D. University of Michigan (Major: Pharmacology)

Positions Held:

• 1971-1975 Research Assistant - Institute for Lipid Research, Baylor College of Medicine, Houston, Texas
• 1981-1983 Visiting Fellow, Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland
• 1983-1986 Senior Staff Fellow, Laboratory of Experimental Therapeutics and Metabolism, National Cancer Institute, NIH, Bethesda, Maryland
• 1986-1990 Assistant Professor, Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas, Austin, Texas
• 1990-1995 Associate Professor, Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas, Austin, Texas
• 1995-2003 Professor, Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas, Austin, Texas
• 1996-2003 Director, Toxicology Training Program, College of Pharmacy, The University of Texas, Austin, Texas
• 1996-2003 Adjunct Professor, Department of Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Science Park Research Division, Smithville, Texas
• 1996-2003 Director, Analytical Instrumentation Facility Core, Center for Research on Environmental Disease
• 2003-present Professor, Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona
• 2003-present Director, Southwest Environmental Health Sciences Center, Center for Toxicology, University of Arizona, Tucson, Arizona
  

Professional Societies:

• Phi Kappa Phi
• Mortar Board
• Alpha Lamda Delta
• Rho Chi
• American Association of Colleges of Pharmacy
• American Association for the Advancement of Science
• American Society of Mass Spectrometry
• American Society of Pharmacology and Experimental Therapeutics
• International Society for the Study of Xenobiotics
• Society of Toxicology
• American Chemical Society
• American Association for Cancer Research
• Association of Biomolecular Resource Facilities

Honors and other Special Scientific Recognition:

• Rackham Block Grant, University of Michigan, 1975-1976.
• Pharmacology Fellowship, University of Michigan, 1975-1976.
• Barbour Scholarship, University of Michigan, 1976-1978.
• University of Michigan Cancer Research Grant, 1977.
• Hoffman-LaRoche Fellowship, University of Michigan, 1978-1980.
• Rackham Dissertation Grant, University of Michigan, 1979.
• Best Paper Award of Drug Metabolism and Disposition, 1985. Awarded by the Drug Metabolism Division of American Society of Pharmacology and Experimental Therapeutics. Paper entitled “Glutathione Conjugates of 2-Bromohydroquinone are Nephrotoxic.”
• Nominated for the Best Paper Award of Drug Metabolism and Disposition, 1987,
  • Paper title: Cooxidation of 2-bromohydroquinone by renal prostaglandin synthase. Modulation of prostaglandin synthesis by 2-bromohydroquinone and glutathione.
• Nominated for the Texas Excellent Teaching Award of the College of Pharmacy, The University of Texas for the years of 1989 and 1990.
• Alfred and Dorothy Mannino Fellow of College of Pharmacy, University of Texas at Austin, 1988-1993.
  • She represents the first Endowed Assistant Professor in the history of the College of Pharmacy at the University of Texas.
• Alan W. Hamm Centennial Fellow of College of Pharmacy, University of Texas at Austin, 1993-1995.
• Behrens Centennial Professor in Pharmacy, University of Texas at Austin, 1995-1996.
• Johnson and Johnson Centennial Professor in Pharmacy, University of Texas at Austin, 1996-2003.
• Society of Toxicology Education Award, 2009.
• 2009 Distinguished Chinese Toxicologist Lectureship Award, sponsored by the American Association of Chinese in Toxicology, SOT special interest group.

Publications (Selected from >150):

• Cohen, J.D., Gard, J.M.C., Nagle, R.B., Dietrich, J.D., Monks, T.J., and Lau, S.S. ERK crosstalks with 4EBP1 to activate cyclin D1 translation during quinol-thioether induced Tuberous Sclerosis renal cell carcinoma. Toxicol. Sci., in press, 2011.

 

• Hattan, C.M., Shojaie, J., Lau, S.S. and Anders, M.W. Synthesis of 3-(1-Methyl-1H-imidazol-2-ylthio)propanoic acid and (E)-3-(1-Methyl-1H-imidazol-2-ylthio)acrylic acid, Synth. Commun. in press 2011.

• Cohen, J.D., Tham, K.Y., Mastrandrea, N.M., Gallegos, A.C., Monks, T.J., Lau, S.S. cAMP–Dependent Pathway(s) Directs the Rap-GTP/B-Raf MAPK Mediated Cytosolic Mislocalization of p27kip-cyclin D1 in Renal Cancer. Toxicol. Sci. 122(20:361-371, 2011.

• Fisher, A.A., Labenski, M.T., Malladi, S., Chapman, J.D., Bratton, S.B., Monks, T.J. and Lau, S.S. The frequency of 1,4-benzoquinone-lysine adducts in cytochrome c correlate with defects in apoptosome activation, Toxicol. Sci. 122(1): 64-72, 2011.

• Felter, S.P., Conolly, R.B., Bercu, J.P., Bolger, P.M., Boobis, A.R., Bos, P.M.J., Carthew, P., Doerrer, N.G., Goodman, J.I., Harrouk, W.A., Kirkland, D.J., Lau, S.S., Llewellyn, G.C., Preston, R.J., Schoeny, R., Schnatter, A.R., Tritscher A., van Velsen, F. and Williams, G.M. A proposed framework for assessing risk from less-than-lifetime exposures to carcinogens, Critical Reviews in Toxicology. 41: 507-544, 2011.

• Kimzey, M.J., Zarate, X., Galbraith, D.W. and Lau, S.S. Optimizing microarray-based in situ transcription-translation of proteins for MALDI mass spectrometry, Anal. Biochem. 414: 282-286, 2011.

• Kimzey, M.J., Yassine, H.N., Riepel, B.M., Tsaprailis, G., Monks, T.J. and Lau, S.S. New Site(s) of Methylglyoxal-modified human serum albumin, identified by multiple reaction monitoring, alter warfarin binding and prostaglandin metabolism. Chemico-Biol Int. 192: 122-128, 2011.

• Zhang, F., Lau, S.S. and Monks, S.S. The cytoprotective effect of N-acetyl-L-cysteine against ROS-induced cytotoxicity is independent of its ability to enhance glutathione synthesis, Toxcol. Sci. 120: 87-97, 2011.

• Lau, S.S., Kuhlman, C., Shawn B. Bratton S.B. and Monks, T.J. Role of Hydroquinone-Thiol Conjugates in Benzene-Mediated Toxicity. Chemico-Biol Int., 184: 212-217, 2010.

• Monks, T.J., Butterworth, M., and Lau, S.S. The fate of Benzene Oxide. Chemico-Biol Int., 184:201-206, 2010.

• Fisher, A.A., Labenski, M.T., Monks, T.J., and Lau, S.S. Mass spectrometry-based methods to identify chemical modifications on proteins. I. Utilization of MALDI-TOF to determine chemical-protein adduct formation in vitro. In: Gautier, J.-C. (ed.). Drug Safety Evaluation Series - Methods of Molecular Medicine. Humana Press 2010; 303-16.

• Fisher, A.A., Labenski, M.T., Monks, T.J, and Lau, S.S. Mass spectrometry-based methods to identify chemical modifications on proteins: II. Utilization of LC-MS/MS analyses to identify site-specific chemical protein adducts in vitro. In: Gautier, J.-C. (ed.). Drug Safety Evaluation Series - Methods in Molecular Medicine. Humana Press 2010; 317-26.

• Labenski, M.T., Fisher, A.A., Monks, T.J., and Lau, S.S. Mass spectrometry-based methods to identify chemical modifications on proteins. III. One dimensional western blotting coupled to LC-MS/MS analysis to identify chemical-adducted proteins in urine. In: Gautier, J.-C. (ed.). Drug Safety Evaluation Series - Methods of Molecular Medicine. Humana Press 2010; 327-38.

• Labenski, M.T., Fisher, A.A., Monks, T.J., and Lau, S.S. Mass spectrometry-based methods to identify chemical modifications on proteins. IV. Identification of chemical-adducted proteins in urine by multi-dimensional protein identification technology (LC/LC-MS/MS). In: Gautier, J.-C. (ed.). Drug Safety Evaluation Series - Methods of Molecular Medicine. Humana Press 2010; 339-50.

• Leinweber, B.D., Tsaprailis, G., Monks, T.J., and Lau, S.S. Improved MALDI-TOF imaging yields increased protein signals at high molecular mass. J. Am. Soc. for Mass Spectrometry, 20: 89-95, 2009.

• Labenski, M.T., Fisher, A.A., Lo, H.H., Monks, T.J. and Lau, S.S. Protein electrophile-binding motifs: lysine rich proteins are preferential targets of quinones. Drug Metab. and Disp., 37: 1211-1218, 2009. 

• Perfetti, X., O'Mathuna, B., Pizarro, N., Cuyas, E., Khymenets, O., Almeida, B., Pellegrini, M., Pichini, S., Monks, T.J., Lau, S.S., Farre, M., Pascual, J.A., Joglar, J., de La Torre, R. Neurotoxic thioether adducts of MDMA identified in human urine after Ecstasy ingestion. Drug Metab. and Disp, 37: 1448-1455, 2009.

• Erives, G.V., Lau, S.S., and Monks, T.J. Accumulation of neurotoxic thioether metabolites of 3,4-(±)-methylenedioxymethamphetamine in rat brain. J. Pharmacol. Exp. Ther., 324:284-292, 2008.

• Pizarro, N., de la Torre, R., Joglar, J., Okumura, N., Perfetti, X., Lau, S.S. and Monks, T.J. Serotonergic neurotoxic metabolites of 3,4-(±)-methylenedioxymethamphetamine (MDMA, “Ecstasy”): Synthesis isolation and characterization of diastereoisomers. Chem. Res. Toxicol., 21 (12) 2272-2279, 2008.

• Wozniak R.J., Klimecki, W.T., Lau, S.S., Feinstein, Y., Futscher, B.W. 5-aza-2'-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation.  Oncogene  26:77-90, 2007.

• Fisher, A.A., Labenski, M.T., Gokhale, V., Bowen, M.E., Milleron, R.S., Bratton, S.B., Monks, T. J. and Lau, S.S. Quinone electrophiles selectively adduct “electrophile binding motifs” within cytochrome c. Biochemistry, 46:11090-11100, 2007.

• Yang M.Y., Lau S.S., and Monks T.J. 2,3,5-tris(Glutathion-S-yl)hydroquinone (TGHQ)-mediated apoptosis of human promyelocytic leukemia cells is preceded by mitochondrial cytochrome c release in the absence of a decrease in the mitochondrial membrane potential. Toxicol Sci. 2005 Jul; 86(1):92-100.

• National Research Council Committee on Human Health Risks of Trichloroethylene.  Assessing Human Health Risks of Trichloroethylene: Key Scientific Issues.  Washington, DC: National Academies Press, 2006.

• Eblin, K.E., Bowen, M.E., Cromey, D., Bredfeldt, T.G., Mash, E.A., Lau, S.S. and Gandolfi, A.J. Arsenite and monomethylarsonous acid generate oxidative stress response in human bladder cell culture. Toxicol. Appl. Pharmacol. 217:7-14, 2006.

• Monks, T.J., Xie, R., Tikoo, K. and Lau, S.S. ROS-induced histone modifications and their role in cell survival and cell death. Drug Metab. Rev. 38:755-767, 2006.

• Monks, T.J. and Lau, S.S.  Chemical-induced nephrocarcinogencity in the Eker rat: A model of chemical-induced renal carcinogenesis.  In: Toxicology and the Kidney (L.H. Lash and J.B. Tarloff, Eds., CRC Press), p. 343-374, 2005.

• Person, M.D., Mason, D.E., Liebler, D.C., Monks, T.J. and Lau, S.S. Alkylation of cytochrome c by  (glutathione-S-yl)-1,4-benzoquinone and iodoacetamide demonstrates compound- dependent site specificity. Chem. Res. Toxicol., 18:41-50, 2005.

• Jia, Z., Person, M.D., Dong, J., Shen, J, Hensley, S. C., Stevens , J.L., Monks, T.J. and Lau, S.S. GRP78 is essential for 11-deoxy, 16,16-dimethyl prostaglandin E₂ mediated cytoprotection in renal epithelial cells. Am. J. Physiol. (Renal Physiol), 287: F1113-F1122, 2004. (Editorial Highlighted).

• Yoon, H.S., Ramachandiran, S., Monks, T.J. and Lau, S. S. The tuberous sclerosis-2 tumor suppressor modulates ERK and B-raf activity in transformed renal epithelial cells. Am. J. Physiology, 286:F417-424, 2004.

• Patel, S.K., Ma, N., Monks, T.J. and Lau, S.S. Changes in gene expression during chemical-induced nephrocarcinogenicity in the Eker rat. Mol. Carcinogenesis, 38:141-154, 2003.

• Person, M.D., Lo, H.-H., Towndrow, K. M., Jia, Z., Monks, T. J. and Lau, S. S. Comparative identification of proteins by LC-ESI-MS/MS and MALDI-TOF mass spectrometry. Chem. Res. Toxicol. 16: 757-767, 2003.

• Person, M.D., Monks, T.J., and Lau, S.S. An integrated approach to identifying chemically induced posttranslational modifications using comparative MALDI-MS and targeted HPLC-ESI-MS/MS. Chem. Res, Toxicol. 16: 598-608, 2003.

• Habib, S.L., Phan, M.N., Patel, S.K., Li, D., Monks, T.J. and Lau, S.S. Reduced constitutive 8-oxoguanine-DNA glycosylase expression and impaired induction following oxidative DNA damage in the tuberin deficient Eker rat. Carcinogenesis  24:573-582, 2003.

• Towndrow, K.M., Jia, Z., Lo, H.-H., Person, M. D., Monks, T. J. and Lau, S. S. 11-Deoxy, 16,16-dimethyl prostaglandin E₂ induces specific proteins in association with its ability to protect against oxidative stress. Chem. Res. Toxicol. 16: 312-319, 2003.

• Yoon, H.S., Monks, T.J., Everitt, J.I., Walker, C.L. and Lau, S.S. Cell Proliferation is insufficient but loss of tuberin is necessary for chemical-induced nephrocarcinogenicity in the Eker rat. Am. J. Physiology, 283: F262-F270, 2002.

• Yoon, H.S., Walker, C.L., Monks, T.J., and Lau, S.S. Transformation of kidney epithelial cells by quinol-thioethers via inactivation of the tuberous sclerosis-2 tumor suppressor gene. Mol. Cancinogenesis 31:37-45, 2001.

• Weber, T.J., Huang, Q., Monks, T.J., and Lau, S.S. Differential regulation of redox responsive transcription factors by the nephrocarcinogen 2,3,5-tris(glutathion-S-yl)hydroquinone. Chem. Res. Toxicol. 14:814-821, 2001.

• Lau, S.S., Monks, T. J., Everitt, J.I., Kleymenova, E., and Walker, C.L. Carcinogenicity of a nephrotoxic metabolite of the “nongenotoxic” carcinogen hydroquinone. Chem. Res. Toxicol.  14:25-33, 2001.

• Towndrow, K.T., Mertens, J.J.W., Jeong, J.K., Weber, T.J., Monks, T.J., and Lau, S.S. Stress- and growth-related gene expression are independent of chemical-induced prostaglandin E2 synthesis in renal epithelial cells. Chem. Res. Toxicol.  13:111-117, 2000.

• Kleiner, H.E., Rivera, M.I., Pumford, N.R., Monks, T.J., and Lau, S.S. Immunochemical detection of quinol-thioether derived protein adducts. Chem. Res. Toxicol. 11:1283-1290, 1998.

• Kleiner, H.E., Jones, T.W., Monks, T.J., and Lau, S.S. Immunochemical analysis of quinol-thioether derived covalent protein adducts in rodent species sensitive and resistant to quinol-thioether mediated nephrotoxicity. Chem. Res. Toxicol.  11:1291-1300, 1998.