Aikseng Ooi

The roles of NRF2 in arsenic induced malignant transformation

This pilot project aims to determine the interplay between arsenic‐induced redistribution of DNA methylation sites and NRF2 activation, and how these interactions promote the associated cellular transformation. The completion of this project will not only provide a better understanding of the roles of NRF2 in arsenic‐ induced cellular transformation, it will also provide insights into how NRF2 induction by chemopreventive compounds differs from that by carcinogens. The project exploits the latest in genomic techniques to perform high‐resolution characterization of NRF2 binding sites.

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