(UAHS In The Pharmacy Spotlight)
Catharine Smith, PhD. was recruited to the UA College of Pharmacy as an Associate Professor (tenure eligible) from the NIH in 2006, and has been mentored by SWEHSC members Drs. Bernard Futscher and Myron Jacobson.
Histone deacetylases (HDACs) remove acetyl groups from proteins. Small molecule inhibitors of these enzymes have shown promise in clinical trials as anti-cancer agents, especially when used against hematologic malignancies. However, some environmental xenobiotics have HDAC-inhibiting activity and may act as endocrine disruptors with adverse effects on human health. It is currently difficult to predict and monitor tumor response to HDAC inhibitors (HDIs) as well as determine environmental exposures that have a significant impact on cellular function.
Each year many SWEHSC researchers host high school students in their laboratories. Facility managers assits them process their samples and understand their data. SWEHSC members teach them about toxicology and environmental health. The program was designed by the SWEHSC Outreach Core and is conducted in collaboration with the BIO5 Instutue. Read more about this year's program
The goal of the pilot project is to determine whether arsenic induces changes in the mitochondrial acetylome that are consistent with its documented ability to disrupt energy metabolism. Progress in this project has focused on working closely with Dr.