Catharine Smith

Histone Deacetylases (HDACs) and adverse effects on Human Health

Histone deacetylases (HDACs) remove acetyl groups from proteins. Small molecule inhibitors of these enzymes have shown promise in clinical trials as anti-cancer agents, especially when used against hematologic malignancies. However, some environmental xenobiotics have HDAC-inhibiting activity and may act as endocrine disruptors with adverse effects on human health. It is currently difficult to predict and monitor tumor response to HDAC inhibitors (HDIs) as well as determine environmental exposures that have a significant impact on cellular function.

UA Science Internship Pairs High School Students, Research Mentors

Each year many SWEHSC researchers host high school students in their laboratories. Facility managers assits them process their samples and understand their data. SWEHSC members teach them about toxicology and environmental health. The program was designed by the SWEHSC Outreach Core and is conducted in collaboration with the BIO5 Instutue. Read more about this year's program

Subscribe to RSS - Catharine Smith