Eli Chapman

Stress Response, p97, and Nrf2 in Arsenic-Mediated Toxicity

With pilot project funds we were able to collect sufficient preliminary data to successfully compete for an R01 (ES023758). The preliminary data collected were able to show p97 is directly affected by arsenic. In particular, the ATPase rate of p97 is increased in the presence of arsenic. This was meaningful because a series of genetic lesions has been shown to cause an increase in p97 ATPase activity, which leads to a compromise of autophagy.

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