SWEHSC & WEST Water and Environmental Health Event
Exposure to specific environmental toxicants is an established major public health concern. Hypochlorous acid (HOCI) is the active oxidizing principle released by standard disinfectants used on a global scale during processing of fresh water for human use.
The Pilot Project was designed to generate strong preliminary experimental evidence in human skin reconstructs and mouse skin to confirm the feasibility of cutaneous Nrf2 upregulation using topical cinnamaldehyde (CA) and to support CA-based suppression of photocarcinogenesis in a SKH1-Nrf2 wild type mouse model. Data indicate that CA causes a Keap1-C151-dependent increase in the Nrf2 half-life via blockage of ubiquitination with upregulation of a broad panel of cytoprotective Nrf2 target genes and elevation of cellular glutathione.