Georg Wondrak

Pilot studies examining cinnamon-based Nrf2 activation targeting arsenic-impairment of skin wound healing

The Pilot Project was designed to generate strong preliminary experimental evidence in human skin reconstructs and mouse skin to confirm the feasibility of cutaneous Nrf2 upregulation using topical cinnamaldehyde (CA) and to support CA-based suppression of photocarcinogenesis in a SKH1-Nrf2 wild type mouse model. Data indicate that CA causes a Keap1-C151-dependent increase in the Nrf2 half-life via blockage of ubiquitination with upregulation of a broad panel of cytoprotective Nrf2 target genes and elevation of cellular glutathione.

Cinnamon-Based Nrf2 Activation Targeting Arsenic-Potentiation of Solar Skin Carcinogenesis

The overall NIEHS-directed project (R01-application Zhang/Wondrak; co-PIs) tests feasibility of Nrf2-directed intervention blocking arsenic potentiation of solar skin carcinogenesis, employing topical and dietary administration of the cinnamon constituent cinnamaldehyde (CA).  The pilot project was designed to generate strong preliminary experimental evidence in human skin reconstructs and mouse skin confirming feasibility of cutaneous Nrf2 upregulation using topical CA and supporting CA-based suppression of photocarcinogenesis in a SKH1-Nrf2 wt mouse model.

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