Jeong-Yeol Yoon

Continued funding for liver/kidney on-a-chip for environmental toxicology studies

World-wide exposure to aristolochic acid (AA) via contaminated wheat grain and Chinese herbal medicines is substantial (~100 million), with a significant number of exposed individuals (~5%) succumbing to AA nephropathy (AAN). The mechanism of AA-induced nephrotoxicity, and the molecular basis for susceptibility to AAN remain unknown. AA is metabolized via CYP primarily via O-demethylation to the corresponding hydroxyl metabolite, AA1a, and by nitroreductases to a mutagenic N-hydroxy intermediate.

Liver/kidney on-a-chip for environmental toxicology studies

World-wide exposure to aristolochic acid (AA) via contaminated wheat grain and Chinese herbal medicines is substantial (~100 million), with a significant number of exposed individuals (~5%) succumbing to AA nephropathy (AAN). The mechanism of AA-induced nephrotoxicity, and the molecular basis for susceptibility to AAN remain unknown. AA is metabolized via CYP primarily via O-demethylation to the corresponding hydroxyl metabolite, AA1a, and by nitroreductases to a mutagenic N-hydroxy intermediate.

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