Scott Burchiel

Synthesis and Preliminary Immunotoxicological Investigators on As-GSH conjugates

The central question to be addressed in this Pilot Project is whether glutathione conjugates, which we know are formed in vivo and in vitro, contribute to the differential toxicity of lymphoid cells resulting from differential exposures of these cells and tissues. AsIII(GS)3 and MMAIIIGS2 may be selectively delivered to other cells/tissues enriched in γ-GT (and GSH transporters), including the kidney and brain, providing a sound rationale for extending investigations into the role of these conjugates into other areas of arsenic toxicology. Dr.

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