Terrence J. Monks

In the Parmacy Spotlight

Brian Erstad, PharmD, has been selected as head of the Department of Pharmacy Practice and Science in the College of Pharmacy effective March 18. A member of the department since 1988, Erstad has served as interim head since February 2012. He was assistant department head from 1997 through 2011.

Continued funding for liver/kidney on-a-chip for environmental toxicology studies

World-wide exposure to aristolochic acid (AA) via contaminated wheat grain and Chinese herbal medicines is substantial (~100 million), with a significant number of exposed individuals (~5%) succumbing to AA nephropathy (AAN). The mechanism of AA-induced nephrotoxicity, and the molecular basis for susceptibility to AAN remain unknown. AA is metabolized via CYP primarily via O-demethylation to the corresponding hydroxyl metabolite, AA1a, and by nitroreductases to a mutagenic N-hydroxy intermediate.

Research

The SWEHSC plays an important role in stimulating collaborative interactions among researchers. This is evidenced by a significant number of new, funded research projects, as well as a notable number of planned initiatives involving collaborations. The SWEHSC promotes and enhances collaborative research within and between the members through Research Focus Groups.

The themes of the three Research Focus Groups are seen below:

Synthesis and Preliminary Immunotoxicological Investigators on As-GSH conjugates

The central question to be addressed in this Pilot Project is whether glutathione conjugates, which we know are formed in vivo and in vitro, contribute to the differential toxicity of lymphoid cells resulting from differential exposures of these cells and tissues. AsIII(GS)3 and MMAIIIGS2 may be selectively delivered to other cells/tissues enriched in γ-GT (and GSH transporters), including the kidney and brain, providing a sound rationale for extending investigations into the role of these conjugates into other areas of arsenic toxicology. Dr.

UA Science Internship Pairs High School Students, Research Mentors

Each year many SWEHSC researchers host high school students in their laboratories. Facility managers assits them process their samples and understand their data. SWEHSC members teach them about toxicology and environmental health. The program was designed by the SWEHSC Outreach Core and is conducted in collaboration with the BIO5 Instutue. Read more about this year's program

Liver/kidney on-a-chip for environmental toxicology studies

World-wide exposure to aristolochic acid (AA) via contaminated wheat grain and Chinese herbal medicines is substantial (~100 million), with a significant number of exposed individuals (~5%) succumbing to AA nephropathy (AAN). The mechanism of AA-induced nephrotoxicity, and the molecular basis for susceptibility to AAN remain unknown. AA is metabolized via CYP primarily via O-demethylation to the corresponding hydroxyl metabolite, AA1a, and by nitroreductases to a mutagenic N-hydroxy intermediate.

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