The long-term goal of this research is to facilitate risk assessment, the discovery of infertility- and phthalate-related toxicity biomarkers, and the development of treatments and prevention strategies for infertility in women by identifying and characterizing the cellular and molecular mechanisms by which environmentally relevant exposure to phthalates interact with the ovary. Studies in animal models suggest that phthalates might impair fertility through their ability to disrupt ovarian function.
Dr. Zelieann R. Craig is an Assistant Professor in the School of Animal and Comparative Biomedical Sciences at the University of Arizona in Tucson, AZ. Dr. Craig received her Bachelor's of Science in Industrial Microbiology from the University of Puerto Rico at Mayagüez in 2004 and her Ph.D. in Physiological Sciences from the University of Arizona in 2009. Dr.
Di-n-butyl phthalate (DBP) is a phthalate ester formed by the reaction of n-butanol with phthalic anhydride. DBP is commonly found in latex adhesives, cellulose acetate plastics, dyes, personal care products, and the enteric coating of some oral medications. DBP is an environmental chemical of interest because it can be released to the environment during its production and incorporated into products, as well as from products themselves as they are used and disposed. DBP is a chemical of concern in the study of breast cancer because it has been shown to bind and activate the estrogen rece