TCE Teratogenicity in the Embryonic Heart

Relevance to Swehsc : 

Clean drinking water is precious in the arid Southwest.  One of the most ubiquitous pollutants to drinking water in the Southwest is trichloroethylene (TCE).  The carcinogenic potential of TCE was recently upgraded and our previous studies were the first to link TCE to heart birth defects in a human population.

Cluster of Efforts: 


  • Raymond Runyon, PhD
  • The expression of specific CYPs in the embryonic heart early in development may explain the specific sensitivity of the developing heart to environmental agents prior to liver development.  This work was submitted to NIEHS for funding.  A pilot project has been funded to address reviewer comments on the R01.