Relation of dietary inorganic arsenic to serum matrix metalloproteinase-9 (MMP-9) at different threshold concentrations of tap water arsenic

Relevance to SWEHSC: 

Arsenic (As) exposure is associated with cancer, lung and cardiovascular disease, yet the mechanisms involved are not clearly understood. Elevated matrix metalloproteinase-9 (MMP-9) levels are also associated with these diseases, as well as with exposure to water As. Exposure to iAs from food and water combined, in areas where tap water As concentration is ≤10 μg/l, may contribute to As-induced changes in a biomarker associated with toxicity.

Cluster of Efforts: 


  • Margaret Kurzius-Spencer, PhD
  • Robin B. Harris, PhD
  • Mary Kay O’Rourke, PhD
  • Jefferey L. Burgess MD, MS, MPH
  • Dietary arsenic exposure exceeds that of exposure in drinking water, and also contributes to the increased expression of serum matrix metalloproteinase 9 (MMP-9), a biomarker of arsenic effects that might be associated with cancer and/or lung tissue destruction.
  • Aggregate iAs intake from food and water sources, at exposure levels averaging <20 μg/day, may contribute to As-induced changes in serum MMP-9.
  • Dietary iAs alone was associated with serum MMP-9 at the lowest strata of tap water As, ≤3 μg/l.
  • Association of dietary iAs alone and aggregate iAs exposure with serum MMP-9 was found only among subjects exposed to lower levels of tap water As.
  • Tap water As and drinking water As intake were higher in non-Hispanic households.