Biomarkers and genetic factors related to sarcopenia in women

Relevance to SWEHSC: 

The demographics of the southwest follows the larger trend of an aging population. Debilitating muscle loss in aging women, called sarcopenia, results in significant morbidity and quality-of-life loss. Sarcopenia is associated with a generalized pro-inflammatory state that may be influenced by environmental factors as well as by genetic predisposition.

Cluster of Efforts: 

Investigators/Funding: Z. Chen (RFG1), Klimecki (RFG1), Guerra (RFG1) NIA/AG027979

Chen ZhaoWalt Klimecki

  • This project utilizes samples from the Women's Health Initiative cohort, including participants from Tucson to measure inflammatory protein markers in blood and genetic variants in DNA to understand the underlying pathogenic processes in sarcopenia.
  • Data analysis currently in progress. NIA/AG027979
  • Dr. Chen was awarded a pilot project to study a local cohort of sarcopenic women to test the hypothesis that arsenic exposure is associated with a pro-inflammatory state, and indirectly to muscle loss and loss of bone mineral density. NIEHS ES06694