Oral Folate, arsenic, and genetic polymorphisms: Impact on breast cancer

Relevance to SWEHSC: 

Low circulating folate levels are associated with a higher prevalence of ER-negative breast cancer, as well as less efficient arsenic methylation -- a phenotype associated with increased disease risk for known arsenic associated cancers, including bladder and skin.

Cluster of Efforts: 

Investigators/Funding: Klimecki (RFG1), Gandolfi (RFG1), Lizbeth Lopez-Carrillo (INSP [Mexican National Public Health Institute]) USEPA STAG X-96948701


  • This case control study of 2000 women from Northern Mexico will estimate folate consumption from diet, measure arsenic exposure biomarkers, and test genetic polymorphisms in folate metabolism and arsenic metabolism to explore a potential role for arsenic in the relationship between folate and breast cancer.
  • Subject accrual completed, urinary arsenic determinations ongoing, genetic analyses ongoing. NIEHS/ES004940 (Superfund Component Project)