Effect of Environmental Exposures to Arsenic

Relevance to Swehsc : 

Arsenic is a major environmental toxicant, not only in the Southwestern United States, but also throughout the world. Understanding the effects of inhaled arsenic in arid climates is particularly relevant.

Cluster of Efforts: 

Investigators: 

  • Jefferey Burgess, MD, MPH
  • Scott Boitano, PhD
  • Yin Chen, PhD
  • Margaret Kurzius-Spencer, PhD
  • R. Clark Lantz, PhD
Milestones: 
  • Significant decreases in a-1-antitrypsin were seen in induced sputum from adult populations exposed to low levels of arsenic in their drinking water. (Burgess, Boitano, Kurzius-Spencer, Lantz)
  • Children (ages 6-12) who have been exposed to arsenic in their drinking water during in utero and early life show decrements in lung function. (Lantz)
  • In utero and early postnatal inhalation exposure to real world dusts collected at a legacy mine site lead to alterations in lung function (increased airway reactivity). (Boitano, Lantz)
  • Arsenic Exposure through drinking water alters lung expression of genes and proteins involved in epithelial to mesenchymal transition (EMT). (Boitano, Lantz)
  • Animals exposed to arsenic have decreased expression levels of club (Clara) cell secretroy protein (CCSP). (Chen)