Environmental Exposures and Chronic Lung Disease

Relevance to Swehsc : 

The adverse health response to exposures to toxicants is related both to the exposure to the toxicants as well as the genetic make-up of the exposed populations.

Cluster of Efforts: 

Investigators:

  • Jefferey Burgess, MD, MPH
  • Yin Chen, PhD
  • Stefano Guerra, MD, PhD, MPH
  • Fernando Martinez, MD
  • Shane Snyder, PhD
  • Donata Vercelli, MD
Milestones: 
  • Identification of compounds responsible for asthma protection in a farm environment and the underlying mechanisms. (Vercelli, Snyder)
  • Proteomics analysis identified potential biomarkers following exposure to biodiesel. (Burgess)
  • Inhalation of coarse particulate matter disrupts the endothelial barrier function, resulting in increased risk of cardiovascular disease. (Wang)
  • Validation of serum biomarkers associated with the development of chronic obstructive pulmonary disease from cigarette smoking is continuing. (Chen, Guerra, Martinez)
  • Serum levels of CCSP predict mortality in adult populations. (Chen, Guerra, Martinez)