Exposure modeling by proximity to pollution sources and respiratory outcome

Resources: 
  • Characterization of the environmental exposures that worsen outcome in asthmatic children is critical to developing strategies to mitigate this pediatric disease that is reaching epidemic proportions." - Fernando Martinez

  • Click here for more information on Respiratory Outcomes.

Relevance to SWEHSC: 

Characterization of the environmental exposures that worsen outcome in asthmatic children is critical to developing strategies to mitigate this pediatric disease that is reaching epidemic proportions. Understanding the flux of toxicant-contaminated particulates between outdoor sources and the home will be critical to developing accurate exposure estimates in epidemiological studies.

Cluster of Efforts: 
Investigators/Funding: Beamer (RFG2), Martinez (RFG1, IHSFC), Klimecki (RFG1, IHFSC), Billheimer (IHSFC-Biostats) SWEHSC Pilot Project Funding to Dr. Beamer, Superfund Pilot Project Funding to Dr. Beamer
 
Beamer Paloma          Walt Klimecki
Milestones: 
  • SWEHSC Pilot Project will assess pulmonary health risks in children living near major traffic pollution producers (e.g. highways) using data from the Tucson Children's Respiratory Study (CRS) to model exposures to air pollutants. The CRS is a comprehensive prospective study of asthma and allergy outcomes from birth to (currently) age 30.
  • Analysis of study data demonstrates that children with an increased estimated diesel particulate exposure at their birth address have an increased incidence of lower respiratory tract illness (OR=1.5, CI=1.1-2.0) and of lower respiratory tract illness with wheeze (OR=1.7, CI=1.2-2.4) during the first 3 years of life.
  • Children with these higher diesel particulate matter exposures were also more likely to be classified as early wheezers compared to children who never wheezed (OR 3.2, CI=1.9-5.4).
  • Dr. Beamer has used the data from her SWEHSC Pilot Project to prepare a K25 award application, which recently received an outstanding Impact/Priority score of 19.
  • Superfund Pilot Project developed a modeling and measurement framework for assessing transport of contaminated soils and airborne particulates into a residence, their subsequent distribution indoors via resuspension and deposition processes, and removal by cleaning and building exhalation of suspended particles.
  • This data has been recently published (Layton and Beamer, 2009) and was the subject of a National Public Radio interview with Dr. Beamer, and recently featured in Time Magazine http://www.time.com/time/health/article/0,8599,1966870,00.html.

 

SWEHSC Terms: