RFG3 Key Research Highlights

Reactive oxygen species (ROS) are involved in the initiation and progression of a variety of human diseases and toxicities associated with chemical exposure. An understanding of the factors that regulate the cellular response to ROS and of the molecular mechanisms by which they interact with cellular constituents, and the consequences of such interactions, are important fundamental goals of biomedical research. Members of RFG3 investigate the molecular mechanisms by which ROS produce adverse health effects. With Arizona suffering from the highest incidence of skin cancer in the USA, and with diabetes at epidemic proportions in Native American communities, an emphasis on UV exposure and glycooxidative stress are particularly relevant.