RFG3 Key Research Highlights

Reactive oxygen species (ROS) are involved in the initiation and progression of a variety of human diseases and toxicities associated with chemical exposure. An understanding of the factors that regulate the cellular response to ROS and of the molecular mechanisms by which they interact with cellular constituents, and the consequences of such interactions, are important fundamental goals of biomedical research. Members of RFG3 investigate the molecular mechanisms by which ROS produce adverse health effects. With Arizona suffering from the highest incidence of skin cancer in the USA, and with diabetes at epidemic proportions in Native American communities, an emphasis on UV exposure and glycooxidative stress are particularly relevant.

  • "Diabetes is at epidemic proportions in Native American communities, and to a lesser extent in the general population. Understanding the role of environmental stressors on disease outcome holds the promise of improving patient management and potentially identifying new treatment targets.” - Serrine Lau

  • Click here for more information on glycooxidative stress and diabetes.

  • “Basic research into the molecular nature of oxidative stress is being translated into the development of natural product based activators of Nrf-2 to combat the effects of photo-oxidative stress.”- Donna Zhang and Georg Wondrak.

  • Click here for more information on oxidative stress and mechanisms of cell death.

  • “Members of RFG3 promote research into the mechanisms by which various environmental factors (UV light, ROS-generating chemicals, etc) interact with combinations of genes to produce adverse health effects. An emphasis on UV exposure is particularly relevant to the desert southwest, with Arizona suffering from the highest incidence of skin cancer in the USA.” - Terrence Monks

  • Click here for more information on photooxidative damage and skin cancer.