Glyco-oxidative stress modulates diabetes severity

Resources: 
  • "Diabetes is at epidemic proportions in Native American communities, and to a lesser extent in the general population. Understanding the role of environmental stressors on disease outcome holds the promise of improving patient management and potentially identifying new treatment targets.” - Serrine Lau

  • Click here for more information on glycooxidative stress and diabetes.

Relevance to SWEHSC: 

Diabetes is at epidemic proportions in Native American communities, and to a lesser extent in the general population. Understanding the role of environmental stressors on disease outcome holds the promise of improving patient management and potentially identifying new treatment targets.

Cluster of Efforts: 

Lau (RFG3), Stump (RFG3), Billheimer (IHSFC-Biostats), Tsaprailis (Proteomics): Technology and Research Initiative Funds (TRIF), NIEHS/ES006694 Pilot Project, NIDDK/DK083948, NCRR/S10RR022384

Milestones: 
  • Drs. Lau and Stump have collected blood and urine samples from >100 subjects, predominantly of Hispanic ethnicity. Quantification of free MG and MG-adducts in urine is in progress.
  • MS-based proteomics approaches to differentially profile and quantitate serum protein modification by MG in normal subjects and T2D patients, revealed several novel potential biomarkers. One of these, MG-modified fibrinogen is now being validated. This biomarker appears to offer superior discrimination of diabetic complications than conventional biomarkers that capture glucose binding only as glycated hemoglobin (HbA1C)
  • Urinary arsenic metabolites (As)/24 hrs were also measured (Gandolfi, RFG1) in 14 subjects without diabetes and 19 subjects with diabetes. Total urinary As was significantly elevated in diabetes (p

 

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