RFG3

Research

The SWEHSC plays an important role in stimulating collaborative interactions among researchers. This is evidenced by a significant number of new, funded research projects, as well as a notable number of planned initiatives involving collaborations. The SWEHSC promotes and enhances collaborative research within and between the members through Research Focus Groups.

The themes of the three Research Focus Groups are seen below:

Glycooxidative Stress and Diabetes

Diabetes is an excellent example of how environmental factors interact with susceptibility genes leading to poor clinical outcomes. The Hispanic population is particularly affected by the diabetes epidemic, but this predisposition is poorly understood. Glucose levels or glycated hemoglobin (HbA1C) do not successfully predict all individuals at risk of diabetes or diabetes complications.

Oxidative Stress

Mechanisms of cell death are usually classified into two pathways, apoptosis and oncosis/necrosis. Necrosis/oncosis typically occurs in response to toxic injury, including that induced by chemical exposure and reactive oxygen species (ROS). In contrast to apoptosis, oncosis is characterized by cell and organelle swelling that eventually leads to the loss of plasma membrane integrity. The generation of ROS has been implicated in the pathogenesis of renal ischemia/reperfusion injury, and many other pathological conditions.

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