(UAHS-COP In the Pharmacy Spotlight) Donna Zhang, PhD, professor in the Department of Pharmacology and Toxicology, is the principal investigator on two new R01 grants from the National Institutes of Health which will provide more than $3 million in funding for her research.
The first project is “Nrf2, Autophagy and Arsenic Carcinogenesis.” The objective of the research is to investigate the detailed mechanism by which arsenic causes lung cancer. In turn, this will allow investigators to identify markers of exposure to identify populations at risk of developing arsenic-induced lung cancer, as well as to develop tailored therapies for the individuals who already have developed arsenic-induced lung cancer. This project is funded by grant number 1R01 ES0268745, NIH/NIEHS for $1,695,690 over five years.
The second project is "Arsenic, Nrf2 and Autophagy Dysfunction in Type II Diabetes." The objective of the research is to investigate the molecular mechanisms by which arsenic alters the proteotoxic and oxidative stress responses to determine if these alterations aid the onset and progression of diabetes. This project is funded by grant number 1R01 DK109555, NH/NIDDK for $1,896,710 over five years.
Zhang is a member of the University of Arizona Cancer Center Cancer Prevention and Control unit and of the BIO5 Institute.