UA Researchers Develop Novel ‘Lung-on-a-Leaf’ Model to Study Pulmonary Diseases

News Release Date: 
Wednesday, June 20, 2018


Researchers at the University of Arizona College of Medicine – Phoenix have developed a revolutionary “lung on a leaf” to study pulmonary diseases.

Kenneth Knox, MD, professor and associate dean of faculty affairs and development, and Frederic Zenhausern, PhD, MBA, professor and director of the UA Center for Applied NanoBioscience and Medicine, have received a three-year, $750,000 grant from the Arizona Biomedical Research Commission to study lung infections like Valley fever and inflammatory conditions like sarcoidosis in a plant model.

Dr. Knox hopes that by using inactive Coccidioides fungus—the cause of Valley fever—to simulate inflammation, they will be better able to understand how inflammation begins, which will pave the way for new therapies.

Co-investigators are Drs. Knox, Zenhausern and Lacombe; Ting Wang, PhDLouise Hecker, PhD, and Mrinalini Kala, PhD.

Click here to read more about their research.