Analysis of PCB congeners related to cognitive functioning in adolescents

Author Name: 
Newman, J., Gallo, M. V., Schell, L. M., et al.
Publication Date: 
Thursday, January 1, 2009
Private File Attachment: 
Later DeCaprio would work on another project in 2008, however this time as a supporting role to a project leader, who is one of the most prolific authors in this study of persistent pollution in human tissue, LM Schell. This research on Akweasne Mohawk young adults expands the field of knowledge on PCB and other persistent organic pollutants (POPs), such as hexachlorobenzene to “a broad spectrum of biologic, metabolic, and immunologic responses. The potential of these pollutants to impair immune responses and trigger autoimmune disease is of growing concern, given their structural similarity to thyroid hormones and their potential to modulate the mechanisms and interfere with the binding of these hormones. Scbell et al, examine the relationship of different groupings of PCBs, according to chlorination and structure, and anti-thyroid peroxidase antibody, a useful tool in the evaluation of thyroid dysfunction, among 115 young adults of the Akwesasne Mohawk Nation.” (Schell et al 2009) Schell et al speak about the risks that PCB’s and POP’s pose to the thyroid gland, they observe that damage to the thyroid increases risks of various rare illnesses such as Sjogren syndrome and threatens affected Native Americans with a likelihood of rheumatoid arthritis. PCB causes autoimmune dysfunction that affects reproductive outcomes for example increased risk of pregnancy loss. In the case of the Schell et al report, both men and women were studied as the effects of pregnancy loss were not the main focus of the study. The population studied was a median range of 17.8 years old. This study would probably not be interesting to a geriatric specialist obviously. Toxicant levels did not differ by gender. Breast-fed participants had higher levels of HCB and p,p0-DDE than non-breast- fed ones. This shows in the results, those teenagers breastfed had a higher level of DDE than those who did not, strongly suggesting that the HCB and DDE were passed on by the mother. Overall this research is highly conclusive, would be useful for most researchers who want to know more about the topic. The findings were that exposure to background levels of PCBs may in fact increase the risk of acquiring an autoimmune disease and that these progression of diseases would have been caused by toxicant exposures. Further studies were conducted in 2011.