U of A researchers' new approach boosts immune response against lung cancer

Researchers at the University of Arizona R. Ken Coit College of Pharmacy have developed a new strategy that helps the immune system recognize and attack lung cancer tumors more effectively. By packaging a chemotherapy drug and an RNA molecule in a tiny lipid carrier, the team boosted an immune response that slowed tumor growth and enhanced the effects of immunotherapy.

The findings, published in Nature Communications, describe a nanotechnology-based platform that combines the chemotherapy drug paclitaxel with a gene-silencing molecule known as siRNA. The lipid package improves delivery of both therapies to lung tumor cells.

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