RFG3

Highlights (RFG3)

  • Goals: to provide expert evaluation and support for intra- and inter-programmatic research initiatives related to oxidative stress and other molecular mechanisms associated with environmental exposures.
  • Focus: motivating new research initiatives by enabling technologies, and providing SWEHSC investigators access to scientific and educational activities as well as nurturing research opportunities with environmental health experts.

Environmental Impact on Reproductive Health Investigators

The adverse effects of environmental exposures on the reproductive system have been recognized as significant threat to human health.  Through the addition of new faculty and formation of collaborations among them, SWEHSC is now positioned to make significant contributions in this field.  The center now counts with expertise in descriptive and mechanistic reproductive toxicology (Craig) and the reproductive and gynecological health epidemiology (Farland). 

 

Environmental Oxidative Stressors Causing Skin Damage and Carcinogenesis Investigators

Hypochlorous acid (HOCl) is the active oxidizing principle released by standard swimming pool disinfectants used on a global scale, but the health consequences of human exposure inflicted by HOCl (referred to as ‘chlorination stress’) remain largely unknown, posing a major public health concern relevant to populations around the world. Moreover, environmental exposure to solar ultraviolet (UV) radiation is a causative factor in skin photocarcinogenesis.  In an ongoing R21 research project funded by NIEHS since April 2019 (1R21ES029579), Dr. Wondrak, in collaboration with Dr.

Environmental Exposure-Induced Metabolic Disease and Gastrointestinal Damage Investigators

Obesity rates have risen dramatically over the last four decades, and along this same time frame, the use of pesticides and herbicides in the United States has increased substantially, with RoundUp being one of the most widely used herbicides in the agriculture industry since 1980. The work of this pilot grant aims to identify whether increased exposure to glyphosate, the active ingredient in RoundUp, increases susceptibility to metabolic disease via alterations in the gut microbiota.

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