Relevance to SWEHSC:
Identified a mechanism by which arsenic exposure induces unique changes in gene expression using bioinformatics resources in the IHSFC and Genomics FC. This is being developed into a biomarker for arsenic-mediated cancers. Translation of the mechanistic basis of arsenic-mediated transcriptional reprogramming allows for the addressing of arsenic-specific mechanism. It leads to development of a strategy to circumvent arsenic-induced cellular changes. An arsenic-specific mechanism allows for the development of a strategy to circumvent arsenic-induced cellular changes. Somatic gene mutation studies could provide biomarkers to differentiate cancers seen in arsenic-exposed populations from those arising from other lung carcinogens.
Cluster of Efforts:
Investigator(s):
- Aikseng Ooi, PhD.
Milestones:
- Identified a mechanism by which arsenic exposure induces unique changes in gene expression using bioinformatics resources that is being developed into a biomarker for arsenic-mediated cancers.
- Arsenic-specific mechanism allows for the development of a strategy to circumvent arsenic-induced cellular changes.
- Ongoing somatic gene mutation studies could provide biomarkers to differentiate cancers seen in arsenic exposed populations from those arising from other lung carcinogens.