Our Goal
Is to advance multi-investigator mechanistic research focused on chronic human diseases stemming from toxicant exposures affecting populations in the US Southwest.
Our Focus
Is on elucidating the molecular pathways mediating the effects of toxicants with an emphasis on molecular events that influence the development, progression, and treatment of chronic diseases.
Highlights from Our Research
The effects of environmental exposures on the reproductive system and the developing embryo have been recognized as a significant threat to human health.
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Solar ultraviolet (UV) radiation and chlorination stress originating from freshwater disinfection can impact structure and function of skin and other epithelial tissues posing a major public health concern. Small molecule interventions that block solar UV-induced oxidative stress and skin cancer have been identified.
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Cumulative evidence suggests the impact of environmental exposures on metabolic homeostasis and development of disease (including diabetes and obesity).
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Changes to transport and metabolism enzymes in patients with liver disease can place certain individuals at greater risk of toxicity to environmental exposures.
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Exposure of human cells to environmentally relevant levels of arsenic produce new pathologic epigenetic landscapes that participate in malignant transformation and carcinogenesis.
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Development of a novel miRNA promoter microarray platform, which was subsequently used in an epigenomic analysis of human cancers and provided the foundation for a Cancer Disparities U01 grant.
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Identified a mechanism by which arsenic exposure induces unique changes in gene expression using bioinformatics resources in the TRSC and Omics FC that is being developed into a biomarker for arsenic-mediated cancers.
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