RFG3 Research Summaries

At the University of Arizona College of Medicine–Phoenix, Dr. Melissa M. Herbst-Kralovetz leads a translational women’s health research program focused on the vaginal microbiome — the community of bacteria that plays a crucial role in gynecologic health.

A recent study by Drs. Georg Wondrak and Frank Duca explored the effects of drinking chlorinated water on mouse gut microbiota. Their findings revealed a decline in fecal microbiota diversity and notable shifts in fecal bacterial composition. With potential public health implications for humans, these results underscore the need for further research in human subjects.

Toxicological Sciences has showcased a publication by center member Zelieann Craig, PhD, in their featured Tox Spotlight! Craig’s study found that exposure to di-n-butyl phthalate (DBP) – a common ingredient in many personal care products and medications – disrupts follicular reproductive cycles by interfering with the hormone signaling in the ovary responsible for growth, development, and repair. For this reason, exposure to DBP could ultimately lead to reduced fertility and decreased egg number and quality in women.