SWEHSC Water & Environmental Health Networking Event
SWEHSC & WEST Water and Environmental Health Event
Georg Wondrak
Dr. Georg Wondrak Awarded $409,888 from NIEHS for Translational Research on HOCI Impact on Skin Cancer
Exposure to specific environmental toxicants is an established major public health concern. Hypochlorous acid (HOCI) is the active oxidizing principle released by standard disinfectants used on a global scale during processing of fresh water for human use.
Pharmacology and Toxicology Highlights: October 2018
Publications
Pilot studies examining cinnamon-based Nrf2 activation targeting arsenic-impairment of skin wound healing
The Pilot Project was designed to generate strong preliminary experimental evidence in human skin reconstructs and mouse skin to confirm the feasibility of cutaneous Nrf2 upregulation using topical cinnamaldehyde (CA) and to support CA-based suppression of photocarcinogenesis in a SKH1-Nrf2 wild type mouse model. Data indicate that CA causes a Keap1-C151-dependent increase in the Nrf2 half-life via blockage of ubiquitination with upregulation of a broad panel of cytoprotective Nrf2 target genes and elevation of cellular glutathione.
Oxidative Stress and Redox Dysregulation
Epigenetic Actions of Environmental Arsenicals
University of Arizona College of Pharmacy Researchers Discover Molecular Component of Cinnamon Prevents Colorectal Cancer in Mice
Research conducted at the University of Arizona College of Pharmacy and the UA Cancer Center indicates that a compound derived from cinnamon is a potent inhibitor of colorectal cancer.
Georg Wondrak Receives UA Cancer Center Director's Challenge Award for Therapeutic Development
Georg Wondrak elected to lead the American Society for Photobiology as President-elect
Georg Wondrak, Ph.D.
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